AffiliationCancer Research U.K., Paterson Institute for Cancer Research, University of Manchester, Manchester, UK. email@example.com <firstname.lastname@example.org>
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AbstractThe GINS complex is the most recently identified component of the eukaryotic DNA replication machinery and is required both for the initiation of chromosome replication and also for the normal progression of DNA replication forks. Several recent studies suggest that GINS associates at replication forks with the MCM helicase that is responsible for unwinding the parental DNA duplex. Archaea also have an equivalent GINS complex that can interact with MCM and other replisome components. It seems likely that GINS couples MCM to other key proteins at forks, and we discuss here the current literature regarding this important late-comer to the DNA replication field.
CitationA key role for the GINS complex at DNA replication forks. 2007, 17 (6):271-8 Trends Cell Biol.
JournalTrends in Cell Biology
- The GINS complex from Pyrococcus furiosus stimulates the MCM helicase activity.
- Authors: Yoshimochi T, Fujikane R, Kawanami M, Matsunaga F, Ishino Y
- Issue date: 2008 Jan 18
- GINS, a central nexus in the archaeal DNA replication fork.
- Authors: Marinsek N, Barry ER, Makarova KS, Dionne I, Koonin EV, Bell SD
- Issue date: 2006 May
- The CMG (CDC45/RecJ, MCM, GINS) complex is a conserved component of the DNA replication system in all archaea and eukaryotes.
- Authors: Makarova KS, Koonin EV, Kelman Z
- Issue date: 2012 Feb 13
- The GINS complex: structure and function.
- Authors: Kamada K
- Issue date: 2012
- MCM-GINS and MCM-MCM interactions in vivo visualised by bimolecular fluorescence complementation in fission yeast.
- Authors: Akman G, MacNeill SA
- Issue date: 2009 Feb 19