Affiliation
Cancer Research U.K., Paterson Institute for Cancer Research, University of Manchester, Manchester, UK. klabib@picr.man.ac.uk <klabib@picr.man.ac.uk>Issue Date
2007-06
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Show full item recordAbstract
The GINS complex is the most recently identified component of the eukaryotic DNA replication machinery and is required both for the initiation of chromosome replication and also for the normal progression of DNA replication forks. Several recent studies suggest that GINS associates at replication forks with the MCM helicase that is responsible for unwinding the parental DNA duplex. Archaea also have an equivalent GINS complex that can interact with MCM and other replisome components. It seems likely that GINS couples MCM to other key proteins at forks, and we discuss here the current literature regarding this important late-comer to the DNA replication field.Citation
A key role for the GINS complex at DNA replication forks. 2007, 17 (6):271-8 Trends Cell Biol.Journal
Trends in Cell BiologyDOI
10.1016/j.tcb.2007.04.002PubMed ID
17467990Type
ArticleLanguage
enISSN
1879-3088ae974a485f413a2113503eed53cd6c53
10.1016/j.tcb.2007.04.002
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