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    A key role for the GINS complex at DNA replication forks

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    Authors
    Labib, Karim
    Gambus, Agnieszka
    Affiliation
    Cancer Research U.K., Paterson Institute for Cancer Research, University of Manchester, Manchester, UK. klabib@picr.man.ac.uk <klabib@picr.man.ac.uk>
    Issue Date
    2007-06
    
    Metadata
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    Abstract
    The GINS complex is the most recently identified component of the eukaryotic DNA replication machinery and is required both for the initiation of chromosome replication and also for the normal progression of DNA replication forks. Several recent studies suggest that GINS associates at replication forks with the MCM helicase that is responsible for unwinding the parental DNA duplex. Archaea also have an equivalent GINS complex that can interact with MCM and other replisome components. It seems likely that GINS couples MCM to other key proteins at forks, and we discuss here the current literature regarding this important late-comer to the DNA replication field.
    Citation
    A key role for the GINS complex at DNA replication forks. 2007, 17 (6):271-8 Trends Cell Biol.
    Journal
    Trends in Cell Biology
    URI
    http://hdl.handle.net/10541/71279
    DOI
    10.1016/j.tcb.2007.04.002
    PubMed ID
    17467990
    Type
    Article
    Language
    en
    ISSN
    1879-3088
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.tcb.2007.04.002
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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