Tumor expression of major vault protein is an adverse prognostic factor for radiotherapy outcome in oropharyngeal carcinoma.
West, Catharine M L
Slevin, Nicholas J
Valentine, Helen R
Ryder, W David J
Homer, Jarrod J
Hampson, Ian N
AffiliationDepartment of Academic Radiation Oncology, The University of Manchester, Manchester, United Kingdom.
MetadataShow full item record
AbstractPURPOSE: Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport, with the major vault protein (MVP or lung resistance-related protein [LRP]) being the main component. The MVP gene is located on chromosome 16 close to the multidrug resistance-associated protein and protein kinase c-beta genes. The role of MVP in cancer drug resistance has been demonstrated in various cell lines as well as in ovarian carcinomas and acute myeloid leukemia, but nothing is known about its possible role in radiation resistance. Our aim was to examine this in head-and-neck squamous cell carcinoma (HNSCC). METHODS AND MATERIALS: Archived biopsy material was obtained for 78 patients with squamous cell carcinoma of the oropharynx who received primary radiotherapy with curative intent. Immunohistochemistry was used to detect MVP expression. Locoregional failure and cancer-specific survival were estimated using cumulative incidence and Cox multivariate analyses. RESULTS: In a univariate and multivariate analysis, MVP expression was strongly associated with both locoregional failure and cancer-specific survival. After adjustment for disease site, stage, grade, anemia, smoking, alcohol, gender, and age, the estimated hazard ratio for high MVP (2/3) compared with low (0/1) was 4.98 (95% confidence interval, 2.17-11.42; p = 0.0002) for locoregional failure and 4.28 (95% confidence interval, 1.85-9.95; p = 0.001) for cancer-specific mortality. CONCLUSION: These data are the first to show that MVP may be a useful prognostic marker associated with radiotherapy resistance in a subgroup of patients with HNSCC.
CitationTumor expression of major vault protein is an adverse prognostic factor for radiotherapy outcome in oropharyngeal carcinoma. 2007, 69 (1):133-40 Int. J. Radiat. Oncol. Biol. Phys.
JournalInternational Journal of Radiation Oncology, Biology, Physics
- Tumor volume as a prognostic factor in oropharyngeal squamous cell carcinoma treated with primary radiotherapy.
- Authors: Been MJ, Watkins J, Manz RM, Gentry LR, Leverson GE, Harari PM, Hartig GK
- Issue date: 2008 Aug
- Vaults: a ribonucleoprotein particle involved in drug resistance?
- Authors: Mossink MH, van Zon A, Scheper RJ, Sonneveld P, Wiemer EA
- Issue date: 2003 Oct 20
- Reliability of platelet-derived endothelial cell growth factor as a prognostic factor for oral and oropharyngeal carcinomas.
- Authors: Tsuzuki H, Sunaga H, Ito T, Narita N, Sugimoto C, Fujieda S
- Issue date: 2005 Dec
- Expression of the lung resistance protein (LRP) in primary breast cancer.
- Authors: Pohl G, Filipits M, Suchomel RW, Stranzl T, Depisch D, Pirker R
- Issue date: 1999 Nov-Dec
- Prognostic implications of the nuclear localization of Y-box-binding protein-1 and CXCR4 expression in ovarian cancer: their correlation with activated Akt, LRP/MVP and P-glycoprotein expression.
- Authors: Oda Y, Ohishi Y, Basaki Y, Kobayashi H, Hirakawa T, Wake N, Ono M, Nishio K, Kuwano M, Tsuneyoshi M
- Issue date: 2007 Jul