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    Breast cancer risk-assessment models.

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    Authors
    Evans, D Gareth R
    Howell, Anthony
    Affiliation
    Clinical Genetics, Academic Unit of Medical Genetics and Regional Genetics Service, St Mary's Hospital, Manchester M13 0JH, UK. Gareth.evans@cmmc.nhs.uk
    Issue Date
    2007-09
    
    Metadata
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    Abstract
    There are two main questions when assessing a woman for interventions to reduce her risks of developing or dying from breast cancer, the answers of which will determine her access: What are her chances of carrying a mutation in a high-risk gene such as BRCA1 or BRCA2? What are her risks of developing breast cancer with or without such a mutation? These risks taken together with the risks and benefits of the intervention will then determine whether an intervention is appropriate. A number of models have been developed for assessing these risks with varying degrees of validation. With further improvements in our knowledge of how to integrate risk factors and to eventually integrate further genetic variants into these models, we are confident we will be able to discriminate with far greater accuracy which women are most likely to develop breast cancer.
    Citation
    Breast cancer risk-assessment models. 2007, 9 (5):213 Breast Cancer Res.
    Journal
    Breast Cancer Research
    URI
    http://hdl.handle.net/10541/71124
    DOI
    10.1186/bcr1750
    PubMed ID
    17888188
    Type
    Article
    Language
    en
    ISSN
    1465-542X
    ae974a485f413a2113503eed53cd6c53
    10.1186/bcr1750
    Scopus Count
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