AffiliationClinical Genetics, Academic Unit of Medical Genetics and Regional Genetics Service, St Mary's Hospital, Manchester M13 0JH, UK. Gareth.email@example.com
MetadataShow full item record
AbstractThere are two main questions when assessing a woman for interventions to reduce her risks of developing or dying from breast cancer, the answers of which will determine her access: What are her chances of carrying a mutation in a high-risk gene such as BRCA1 or BRCA2? What are her risks of developing breast cancer with or without such a mutation? These risks taken together with the risks and benefits of the intervention will then determine whether an intervention is appropriate. A number of models have been developed for assessing these risks with varying degrees of validation. With further improvements in our knowledge of how to integrate risk factors and to eventually integrate further genetic variants into these models, we are confident we will be able to discriminate with far greater accuracy which women are most likely to develop breast cancer.
CitationBreast cancer risk-assessment models. 2007, 9 (5):213 Breast Cancer Res.
JournalBreast Cancer Research
- Assessing women at high risk of breast cancer: a review of risk assessment models.
- Authors: Amir E, Freedman OC, Seruga B, Evans DG
- Issue date: 2010 May 19
- BRCA1 and BRCA2 mutation predictions using the BOADICEA and BRCAPRO models and penetrance estimation in high-risk French-Canadian families.
- Authors: Antoniou AC, Durocher F, Smith P, Simard J, Easton DF, INHERIT BRCAs program members.
- Issue date: 2006
- Development and testing of a decision aid for breast cancer prevention for women with a BRCA1 or BRCA2 mutation.
- Authors: Metcalfe KA, Poll A, O'Connor A, Gershman S, Armel S, Finch A, Demsky R, Rosen B, Narod SA
- Issue date: 2007 Sep
- Breast-feeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers.
- Authors: Jernström H, Lubinski J, Lynch HT, Ghadirian P, Neuhausen S, Isaacs C, Weber BL, Horsman D, Rosen B, Foulkes WD, Friedman E, Gershoni-Baruch R, Ainsworth P, Daly M, Garber J, Olsson H, Sun P, Narod SA
- Issue date: 2004 Jul 21
- Prospective study of breast cancer risk for mutation negative women from BRCA1 or BRCA2 mutation positive families.
- Authors: Harvey SL, Milne RL, McLachlan SA, Friedlander ML, Birch KE, Weideman P, kConFab Investigators., Goldgar D, Hopper JL, Phillips KA
- Issue date: 2011 Dec