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    Increases in c-Yes expression level and activity promote motility but not proliferation of human colorectal carcinoma cells.

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    Authors
    Barraclough, Jane
    Hodgkinson, Cassandra L
    Hogg, Alison
    Dive, Caroline
    Welman, Arkadiusz
    Affiliation
    Cancer Research UK, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.
    Issue Date
    2007-09
    
    Metadata
    Show full item record
    Abstract
    Increases in the levels and/or activity of nonreceptor tyrosine kinases c-Src and c-Yes are often associated with colorectal carcinogenesis. The physiological consequences of increased c-Yes activity during the early and late stages of tumorigenesis, in addition to the degree of redundancy between c-Yes and c-Src in colorectal cancer cells, remain elusive. To study the consequences of increases in c-Yes levels and activity in later stages of colorectal carcinogenesis, we developed human colorectal cancer cell lines in which c-Yes levels and activity can be inducibly increased by a tightly controlled expression of wild-type c-Yes or by constitutively active mutants of c-Yes, c-YesY537F, and c-Yes Delta t6aa. c-Yes induction resulted in increased cell motility but did not promote proliferation either in vitro or in vivo. These results suggest that in later stages of colorectal carcinogenesis, elevations in c-Yes levels/activity may promote cancer spread and metastasis rather than tumor growth.
    Citation
    Increases in c-Yes expression level and activity promote motility but not proliferation of human colorectal carcinoma cells. 2007, 9 (9):745-54 Neoplasia
    Journal
    Neoplasia
    URI
    http://hdl.handle.net/10541/70464
    DOI
    10.1593/neo.07442
    PubMed ID
    17898870
    Type
    Article
    Language
    en
    ISSN
    1476-5586
    ae974a485f413a2113503eed53cd6c53
    10.1593/neo.07442
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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