Tracer kinetic model-driven registration for dynamic contrast-enhanced MRI time-series data.
Authors
Buonaccorsi, Giovanni AO'Connor, James P B
Caunce, Angela
Roberts, Caleb
Cheung, Susan
Watson, Yvonne
Davies, Karen
Hope, Lynn
Jackson, Alan
Jayson, Gordon C
Parker, Geoff J M
Affiliation
Imaging Science and Biomedical Engineering, University of Manchester, Manchester, UK. giob@manchester.ac.ukIssue Date
2007-11
Metadata
Show full item recordAbstract
Dynamic contrast-enhanced MRI (DCE-MRI) time series data are subject to unavoidable physiological motion during acquisition (e.g., due to breathing) and this motion causes significant errors when fitting tracer kinetic models to the data, particularly with voxel-by-voxel fitting approaches. Motion correction is problematic, as contrast enhancement introduces new features into postcontrast images and conventional registration similarity measures cannot fully account for the increased image information content. A methodology is presented for tracer kinetic model-driven registration that addresses these problems by explicitly including a model of contrast enhancement in the registration process. The iterative registration procedure is focused on a tumor volume of interest (VOI), employing a three-dimensional (3D) translational transformation that follows only tumor motion. The implementation accurately removes motion corruption in a DCE-MRI software phantom and it is able to reduce model fitting errors and improve localization in 3D parameter maps in patient data sets that were selected for significant motion problems. Sufficient improvement was observed in the modeling results to salvage clinical trial DCE-MRI data sets that would otherwise have to be rejected due to motion corruption.Citation
Tracer kinetic model-driven registration for dynamic contrast-enhanced MRI time-series data. 2007, 58 (5):1010-9 Magn Reson MedJournal
Magnetic Resonance in MedicineDOI
10.1002/mrm.21405PubMed ID
17969122Type
ArticleLanguage
enISSN
0740-3194ae974a485f413a2113503eed53cd6c53
10.1002/mrm.21405
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