AuthorsRosa, M I
Medeiros, Lidia Rosi
Bozzetti, M C
Zanini, R R
Moraes, A B
Rosa, Daniela D
AffiliationPostgraduate Program in Epidemiology, Faculty of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, Brazil. firstname.lastname@example.org
MetadataShow full item record
AbstractThe detection of telomerase activity in cervix may provide information on cervical carcinogenesis and may be a marker to monitor cervical intraepithelial neoplasia transition. A quantitative systematic review was performed to estimate the accuracy of telomerase assay in cervical lesions. Studies that evaluated the telomerase test (telomerase repeated amplification protocol) for the diagnosis of cervix lesions and compared it to paraffin-embedded sections as the diagnostic standard were included. Ten studies were analyzed, which included 1069 women. The diagnostic odds ratio (DOR) for a positive telomerase test for low-grade squamous intraepithelial lesions (Lo-SIL) vs normal or benign lesions was 3.2 (95% CI, 1.9-5.6). The DOR for a positive telomerase test for high-grade squamous intraepithelial lesions (Hi-SIL) vs Lo-SIL, normal or benign lesions was 5.8 (95% CI, 3.1-10). For cervix cancer vs Hi-SIL, the DOR for a positive telomerase test was 8.1 (95% CI, 3.2-20.3) and for cervix cancer vs Lo-SIL, normal or benign lesions, it was 40.9 (95% CI, 18.2-91). Our data support the current hypothesis that telomerase may activate an early event in cervical carcinogenesis that could be associated with the initiation and progression of cervical lesions.
CitationAccuracy of telomerase in cervical lesions: a systematic review., 17 (6):1205-14 Int. J. Gynecol. Cancer
JournalInternational Journal of Gynecological Cancer
- Telomerase assay and HPV 16/18 typing as adjunct to conventional cytological cervical cancer screening.
- Authors: Ngan HY, Cheung AN, Liu SS, Liu KL, Tsao SW
- Issue date: 2002 Mar-Apr
- Semiquantitative analysis of telomerase activity in cervical cancer and precancerous lesions.
- Authors: Nagai N, Oshita T, Murakami J, Ohama K
- Issue date: 1999 Mar-Apr
- Amplification of the human telomerase gene in liquid-based preparations is associated with cervical dysplasia and carcinoma.
- Authors: Fan YB, Wu X, Fu ZM, Wu GP
- Issue date: 2010 Mar
- Telomerase expression in normal epithelium, reactive atypia, squamous dysplasia, and squamous cell carcinoma of the uterine cervix.
- Authors: Shroyer KR, Thompson LC, Enomoto T, Eskens JL, Shroyer AL, McGregor JA
- Issue date: 1998 Feb
- [Detection of telomerase activity in cervical lesions by non-radioactive telomeric repeat amplification protocol (TRAP)].
- Authors: Pinto-Tang J, Castro T, Premoli G
- Issue date: 2005 Sep