Authors
Rosa, M IMedeiros, Lidia Rosi
Bozzetti, M C
Fachel, J
Wendland, E
Zanini, R R
Moraes, A B
Rosa, Daniela D
Affiliation
Postgraduate Program in Epidemiology, Faculty of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, Brazil. mir@unesc.netIssue Date
2007
Metadata
Show full item recordAbstract
The detection of telomerase activity in cervix may provide information on cervical carcinogenesis and may be a marker to monitor cervical intraepithelial neoplasia transition. A quantitative systematic review was performed to estimate the accuracy of telomerase assay in cervical lesions. Studies that evaluated the telomerase test (telomerase repeated amplification protocol) for the diagnosis of cervix lesions and compared it to paraffin-embedded sections as the diagnostic standard were included. Ten studies were analyzed, which included 1069 women. The diagnostic odds ratio (DOR) for a positive telomerase test for low-grade squamous intraepithelial lesions (Lo-SIL) vs normal or benign lesions was 3.2 (95% CI, 1.9-5.6). The DOR for a positive telomerase test for high-grade squamous intraepithelial lesions (Hi-SIL) vs Lo-SIL, normal or benign lesions was 5.8 (95% CI, 3.1-10). For cervix cancer vs Hi-SIL, the DOR for a positive telomerase test was 8.1 (95% CI, 3.2-20.3) and for cervix cancer vs Lo-SIL, normal or benign lesions, it was 40.9 (95% CI, 18.2-91). Our data support the current hypothesis that telomerase may activate an early event in cervical carcinogenesis that could be associated with the initiation and progression of cervical lesions.Citation
Accuracy of telomerase in cervical lesions: a systematic review., 17 (6):1205-14 Int. J. Gynecol. CancerJournal
International Journal of Gynecological CancerDOI
10.1111/j.1525-1438.2007.00980.xPubMed ID
17506842Type
ArticleLanguage
enISSN
1048-891Xae974a485f413a2113503eed53cd6c53
10.1111/j.1525-1438.2007.00980.x
Scopus Count
Collections
Related articles
- Semiquantitative analysis of telomerase activity in cervical cancer and precancerous lesions.
- Authors: Nagai N, Oshita T, Murakami J, Ohama K
- Issue date: 1999 Mar-Apr
- Telomerase expression in normal epithelium, reactive atypia, squamous dysplasia, and squamous cell carcinoma of the uterine cervix.
- Authors: Shroyer KR, Thompson LC, Enomoto T, Eskens JL, Shroyer AL, McGregor JA
- Issue date: 1998 Feb
- Upregulation of telomerase (hTERT) is related to the grade of cervical intraepithelial neoplasia, but is not an independent predictor of high-risk human papillomavirus, virus persistence, or disease outcome in cervical cancer.
- Authors: Branca M, Giorgi C, Ciotti M, Santini D, Di Bonito L, Costa S, Benedetto A, Bonifacio D, Di Bonito P, Paba P, Accardi L, Mariani L, Ruutu M, Syrjänen S, Favalli C, Syrjänen K
- Issue date: 2006 Nov
- Telomerase activity as a biomarker for (pre)neoplastic cervical disease in scrapings and frozen sections from patients with abnormal cervical smear.
- Authors: Wisman GB, Hollema H, de Jong S, ter Schegget J, Tjong-A-Hung SP, Ruiters MH, Krans M, de Vries EG, van der Zee AG
- Issue date: 1998 Jun
- Telomerase activity as a tumor marker in Indian women with cervical intraepithelial neoplasia and cervical cancer.
- Authors: Sharma A, Rajappa M, Saxena A, Sharma M
- Issue date: 2007