• Login
    View Item 
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Lung cancer risk and variation in MGMT activity and sequence.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Povey, Andrew C
    Margison, Geoffrey P
    Santibanez-Koref, Mauro F
    Affiliation
    Centre for Occupational and Environmental Health, University of Manchester, United Kingdom. a.povey@manchester.ac.uk
    Issue Date
    2007-08-01
    
    Metadata
    Show full item record
    Abstract
    O(6)-Alkylguanine-DNA alkyltransferase (MGMT) repairs DNA adducts that result from alkylation at the O(6) position of guanine. These lesions are mutagenic and toxic and can be produced by a variety of agents including the tobacco-specific nitrosamines, carcinogens present in cigarette smoke. Here, we review some of our work in the context of inter-individual differences in MGMT expression and their potential influence on lung cancer risk. In humans there are marked inter-individual differences in not only levels of DNA damage in the lung (N7-methylguanine) that can arise from exposure to methylating agents but also in MGMT activity in lung tissues. In the presence of such exposure, this variability in MGMT activity may alter cancer susceptibility, particularly as animal models have demonstrated that the complete absence of MGMT activity predisposes to alkylating-agent induced cancer while overexpression is protective. Recent studies have uncovered a series of polymorphisms that affect protein activity or are associated with differences in expression levels. The associations between these (and other) polymorphisms and cancer risk are inconsistent, possibly because of small sample sizes and inter-study differences in lung cancer histology. We have recently analysed a consecutive series of case-control studies and found evidence that lung cancer risk was lower in subjects with the R178 allele.
    Citation
    Lung cancer risk and variation in MGMT activity and sequence. 2007, 6 (8):1134-44 DNA Repair
    Journal
    DNA Repair
    URI
    http://hdl.handle.net/10541/70378
    DOI
    10.1016/j.dnarep.2007.03.022
    PubMed ID
    17569600
    Type
    Article
    Language
    en
    ISSN
    1568-7864
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.dnarep.2007.03.022
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • O(6)-methylguanine-DNA methyltransferase (MGMT): impact on cancer risk in response to tobacco smoke.
    • Authors: Christmann M, Kaina B
    • Issue date: 2012 Aug 1
    • MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents.
    • Authors: Kaina B, Christmann M, Naumann S, Roos WP
    • Issue date: 2007 Aug 1
    • Development of a new application of the comet assay to assess levels of O6-methylguanine in genomic DNA (CoMeth).
    • Authors: Ramos AA, Pedro DF, Lima CF, Collins AR, Pereira-Wilson C
    • Issue date: 2013 Jul
    • Implication of a Chromosome 15q15.2 Locus in Regulating UBR1 and Predisposing Smokers to MGMT Methylation in Lung.
    • Authors: Leng S, Wu G, Collins LB, Thomas CL, Tellez CS, Jauregui AR, Picchi MA, Zhang X, Juri DE, Desai D, Amin SG, Crowell RE, Stidley CA, Liu Y, Swenberg JA, Lin Y, Wathelet MG, Gilliland FD, Belinsky SA
    • Issue date: 2015 Aug 1
    • Genetic variants in MGMT and risk of lung cancer in Southeastern Chinese: a haplotype-based analysis.
    • Authors: Hu Z, Wang H, Shao M, Jin G, Sun W, Wang Y, Liu H, Wang Y, Ma H, Qian J, Jin L, Wei Q, Lu D, Huang W, Shen H
    • Issue date: 2007 May
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.