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dc.contributor.authorLamb, Rebecca
dc.contributor.authorHarrison, Hannah
dc.contributor.authorClarke, Robert B
dc.date.accessioned2009-06-12T14:21:03Z
dc.date.available2009-06-12T14:21:03Z
dc.date.issued2007
dc.identifier.citationMammary development, carcinomas and progesterone: role of Wnt signalling. 2007 (1):1-23 Ernst Schering Found Symp Procen
dc.identifier.pmid18543432
dc.identifier.urihttp://hdl.handle.net/10541/70377
dc.description.abstractThe mammary gland begins development during embryogenesis but after exposure to hormonal changes during puberty and pregnancy undergoes extensive further development. Hormonal changes are key regulators in the cycles of proliferation, differentiation, apoptosis and remodelling associated with pregnancy, lactation and involution following weaning. These developmental processes within the breast epithelium can be explained by the presence of a long-lived population of tissue-specific stem cells. The longevity of these stem cells makes them susceptible to accumulating genetic change and consequent transformation. The ovarian steroid progesterone, acting via the secreted factor Wnt4, is known to be essential for side branching of the mammary gland. One function of Wnt proteins is self-renewal of adult tissue stem cells, suggesting that progesterone may exert its effects within the breast, at least partly, by regulating the mammary stem cell population.
dc.language.isoenen
dc.subjectMammary Canceren
dc.subject.meshAnimals
dc.subject.meshHumans
dc.subject.meshMammary Glands, Human
dc.subject.meshMammary Neoplasms, Animal
dc.subject.meshProgesterone
dc.subject.meshSignal Transduction
dc.subject.meshStem Cells
dc.subject.meshWnt Proteins
dc.titleMammary development, carcinomas and progesterone: role of Wnt signalling.en
dc.typeArticleen
dc.contributor.departmentBreast Biology Group, Cancer Studies, University of Manchester, Paterson Institute for Cancer Research, Wilmslow Road, M20 4BX Manchester, UK.en
dc.identifier.journalErnst Schering Foundation Symposium Proceedingsen
html.description.abstractThe mammary gland begins development during embryogenesis but after exposure to hormonal changes during puberty and pregnancy undergoes extensive further development. Hormonal changes are key regulators in the cycles of proliferation, differentiation, apoptosis and remodelling associated with pregnancy, lactation and involution following weaning. These developmental processes within the breast epithelium can be explained by the presence of a long-lived population of tissue-specific stem cells. The longevity of these stem cells makes them susceptible to accumulating genetic change and consequent transformation. The ovarian steroid progesterone, acting via the secreted factor Wnt4, is known to be essential for side branching of the mammary gland. One function of Wnt proteins is self-renewal of adult tissue stem cells, suggesting that progesterone may exert its effects within the breast, at least partly, by regulating the mammary stem cell population.


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