Mammary development, carcinomas and progesterone: role of Wnt signalling.
AffiliationBreast Biology Group, Cancer Studies, University of Manchester, Paterson Institute for Cancer Research, Wilmslow Road, M20 4BX Manchester, UK.
MetadataShow full item record
AbstractThe mammary gland begins development during embryogenesis but after exposure to hormonal changes during puberty and pregnancy undergoes extensive further development. Hormonal changes are key regulators in the cycles of proliferation, differentiation, apoptosis and remodelling associated with pregnancy, lactation and involution following weaning. These developmental processes within the breast epithelium can be explained by the presence of a long-lived population of tissue-specific stem cells. The longevity of these stem cells makes them susceptible to accumulating genetic change and consequent transformation. The ovarian steroid progesterone, acting via the secreted factor Wnt4, is known to be essential for side branching of the mammary gland. One function of Wnt proteins is self-renewal of adult tissue stem cells, suggesting that progesterone may exert its effects within the breast, at least partly, by regulating the mammary stem cell population.
CitationMammary development, carcinomas and progesterone: role of Wnt signalling. 2007 (1):1-23 Ernst Schering Found Symp Proc
JournalErnst Schering Foundation Symposium Proceedings
- Wnt signaling pathway in mammary gland development and carcinogenesis.
- Authors: Turashvili G, Bouchal J, Burkadze G, Kolar Z
- Issue date: 2006
- Wnt signalling in murine postnatal mammary gland development.
- Authors: Jardé T, Dale T
- Issue date: 2012 Jan
- Progesterone involvement in breast development and tumorigenesis--as revealed by progesterone receptor "knockout" and "knockin" mouse models.
- Authors: Ismail PM, Amato P, Soyal SM, DeMayo FJ, Conneely OM, O'Malley BW, Lydon JP
- Issue date: 2003 Nov
- The mammary stem cell hierarchy: a looking glass into heterogeneous breast cancer landscapes.
- Authors: Sreekumar A, Roarty K, Rosen JM
- Issue date: 2015 Dec
- Progesterone signaling in mammary gland development.
- Authors: Conneely OM, Mulac-Jericevic B, Arnett-Mansfield R
- Issue date: 2007