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    How will haematologists use proteomics?

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    Authors
    Unwin, Richard D
    Whetton, Anthony D
    Affiliation
    Stem Cell and Leukaemia Proteomics Laboratory, Faculty of Medical and Human Sciences, University of Manchester, Christie Hospital, Kinnaird House, Kinnaird Road, Withington, Manchester, UK M20 4QL. runwin@manchester.ac.uk
    Issue Date
    2007-11
    
    Metadata
    Show full item record
    Abstract
    Proteomics technologies are emerging as a useful tool in the identification of disease biomarkers, and in defining and characterising both normal physiological and disease processes. Many cellular changes in protein expression in response to an external stimulus or mutation can only be characterised at the proteome level. In these cases protein expression is often controlled by altered rates of translation and/or degradation, making proteomics an important tool in the analysis of biological systems. In the leukaemias, post-translational modification of proteins (e.g. phosphorylation, acetylation) plays a key role in the molecular pathology of the disease: such modifications can now be detected with novel proteomic methods. In a clinical setting, serum remains a relatively un-mined source of information for prognosis and response to therapy. This protein rich fluid represents an opportunity for proteomics research to benefit hematologists and others. In this review, we discuss the technologies available for the study of the proteome that offer realistic opportunities in haematology.
    Citation
    How will haematologists use proteomics? 2007, 21 (6):315-26 Blood Rev.
    Journal
    Blood Reviews
    URI
    http://hdl.handle.net/10541/70329
    DOI
    10.1016/j.blre.2007.07.002
    PubMed ID
    17889973
    Type
    Article
    Language
    en
    ISSN
    0268-960X
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.blre.2007.07.002
    Scopus Count
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    All Paterson Institute for Cancer Research

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