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    Adult weight gain and central obesity in women with and without a family history of breast cancer: a case control study.

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    Authors
    Harvie, Michelle N
    Bokhari, Saba
    Shenton, Andrew
    Ashcroft, Linda
    Evans, D Gareth R
    Swindell, Ric
    Howell, Anthony
    Affiliation
    Breast Cancer Prevention Centre, South Manchester University Hospitals NHS Trust, Manchester M20 2LR, UK. Maria.Parker@christie-tr.nwest.nhs.uk
    Issue Date
    2007
    
    Metadata
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    Abstract
    Adult weight gain and central obesity can increase breast cancer risk. We determined the prevalence of adult weight gain and central obesity amongst women with a family history (FH) as compared to women with a population risk to determine whether adiposity could contribute to their increased risk. Adult weight gain, waist and waist:hip ratio (WHR) were determined amongst 475 women (aged 20-60 years) attending a regional FH breast cancer risk clinic, compared to 312 age matched women at population risk. Patterns of adult weight gain did not differ between women with and without a FH of breast cancer. The majority of weight gain occurred between the ages of 20 and 40 in both groups. Mean (sd) weight gain for women aged >40 years with a FH was 8.9 (10.3) kg compared to 9.1 (10.6) kg for controls (p = 0.85). Women with a FH had a significantly greater waist and WHR than controls. Mean (sd) waist was 83.7 (13) cm compared to 81.6 (11.3) cm for controls (p < 0.01). Mean (sd) WHR was 0.82 (0.1) compared to 0.80 (0.1) for controls (p < 0.01). FH of breast cancer was an independent predictor of having a WHR of >0.85; odds ratio (95% CI) = 1.42 (1.01-2.01) (p = 0.044). Significant weight gain between the ages of 20 and 40 and the prevalence of central obesity amongst FH women suggest the need for weight management within FH clinics.
    Citation
    Adult weight gain and central obesity in women with and without a family history of breast cancer: a case control study. 2007, 6 (3):287-94 Fam. Cancer
    Journal
    Familial Cancer
    URI
    http://hdl.handle.net/10541/70313
    DOI
    10.1007/s10689-007-9122-3
    PubMed ID
    17429760
    Type
    Article
    Language
    en
    ISSN
    1389-9600
    ae974a485f413a2113503eed53cd6c53
    10.1007/s10689-007-9122-3
    Scopus Count
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