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    Distortion-corrected T2 weighted MRI: a novel approach to prostate radiotherapy planning.

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    Authors
    Jackson, Andrew
    Reinsberg, S A
    Sohaib, S A
    Charles-Edwards, E M
    Mangar, Stephen A
    South, C P
    Leach, Martin O
    Dearnaley, David P
    Affiliation
    Academic Department of Radiotherapy and Oncology, Royal Marsden Hospital and Institute of Cancer Research, Downs Rd, Sutton SM2 5PT, UK. Andrew.Jackson@manchester.ac.uk
    Issue Date
    2007-11
    
    Metadata
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    Abstract
    The purpose of this study was to evaluate distortion-corrected MRI as a radiotherapy planning tool for prostate cancer and the resultant implications for dose sparing of organs at risk. 11 men who were to be treated with radical conformal radiotherapy for localized prostate cancer had an MRI scan under radiotherapy planning conditions, which was corrected for geometric distortion. Radiotherapy plans were created for planning target volumes derived from the MRI- and CT-defined prostate. Dose volume histograms were produced for the rectum, bladder and penile bulb. The mean volume of the prostate as defined on CT and MRI was 41 cm3 and 36 cm3, respectively (p = 0.009). The predicted percentage of the rectum treated to dose levels of 45-65 Gy was significantly lower for plans delineating the prostate with MRI than for those with CT. The rectal-sparing effect was confined to the lowermost 4 cm of the rectum (anal canal). There were no differences between the predicted doses to bladder or penile bulb (as defined using MRI) between plans. In conclusion, prostate radiotherapy planning based on distortion-corrected MRI is feasible and results in a smaller target volume than does CT. This leads to a lower predicted proportion of the rectum, in particular the lower rectum (anal canal), treated to a given dose than with CT.
    Citation
    Distortion-corrected T2 weighted MRI: a novel approach to prostate radiotherapy planning. 2007, 80 (959):926-33 Br J Radiol
    Journal
    The British Journal of Radiology
    URI
    http://hdl.handle.net/10541/70296
    DOI
    10.1259/bjr/51363812
    PubMed ID
    17908816
    Type
    Article
    Language
    en
    ISSN
    1748-880X
    ae974a485f413a2113503eed53cd6c53
    10.1259/bjr/51363812
    Scopus Count
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