Single fraction radiotherapy for small superficial carcinoma of the skin
Affiliation
Department of Clinical Oncology, Nottingham University Hospital NHS Trust, Hucknall Road, Nottingham NG5 1PB, UK. steve.chan@nuh.nhs.ukIssue Date
2007-05
Metadata
Show full item recordAbstract
AIMS: To define the optimal dose and maximum tumour size of basal and squamous cell carcinoma of skin that can be treated by single fraction radiotherapy. MATERIALS AND METHODS: A review was undertaken of 1005 lesions of basal/squamous cell carcinoma of the skin involving 806 patients treated at a single centre with 10 years of follow-up. Doses of 18, 20 and 22.5 Gy were used. The recurrence and necrosis free survival rates for different anatomical sites and radiation doses were calculated. RESULTS: The overall disease-free and necrosis-free rates at 5 years were 90% and 84%, respectively. The crude 10-year recurrence rate was 4% (95% CI 3.4-5.4%), with late skin necrosis at 6% (95% CI 4.8-7.2%). There was no difference in tumour recurrence rates between 20 and 22.5 Gy (P=0.3), but there was a significantly higher skin necrosis rate at the treated site in the patients who had received 22.5 Gy (P=0.003). Most skin necrosis healed spontaneously, with only 16% requiring surgical intervention. Tumours involving the inner canthus had a significantly higher recurrence rate than those involving other areas of the head and neck. CONCLUSIONS: Single fraction radiotherapy is an acceptable treatment for small superficial BCC and SCC of the head and neck region in patients who have difficulty attending multiple hospital visits as long as the field size required for treatment is no larger than 3 cm in diameter. The optimal applied dose for such a lesion on a flat surface is 20 Gy.Citation
Single fraction radiotherapy for small superficial carcinoma of the skin. 2007, 19 (4):256-9 Clin OncolJournal
Clinical OncologyDOI
10.1016/j.clon.2007.02.004PubMed ID
17379488Type
ArticleLanguage
enISSN
0936-6555ae974a485f413a2113503eed53cd6c53
10.1016/j.clon.2007.02.004
Scopus Count
Collections
Related articles
- Radiotherapy alone for clinical T4 skin carcinoma of the head and neck with surgery reserved for salvage.
- Authors: Al-Othman MO, Mendenhall WM, Amdur RJ
- Issue date: 2001 Nov-Dec
- Craniofacial resection for nonmelanoma skin cancer of the head and neck.
- Authors: Backous DD, DeMonte F, El-Naggar A, Wolf P, Weber RS
- Issue date: 2005 Jun
- Radiotherapy for perineural invasion in cutaneous head and neck carcinomas: toward a risk-adapted treatment approach.
- Authors: Jackson JE, Dickie GJ, Wiltshire KL, Keller J, Tripcony L, Poulsen MG, Hughes M, Allison RW, Martin JM
- Issue date: 2009 May
- Hypofractionated radiotherapy denoted as the "Christie scheme": an effective means of palliating patients with head and neck cancers not suitable for curative treatment.
- Authors: Al-mamgani A, Tans L, Van rooij PH, Noever I, Baatenburg de jong RJ, Levendag PC
- Issue date: 2009
- Radiation therapy for Bowen's disease of the skin.
- Authors: Lukas VanderSpek LA, Pond GR, Wells W, Tsang RW
- Issue date: 2005 Oct 1