• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Small cell lung cancer and targeted therapies

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Blackhall, Fiona H
    Shepherd, Frances A
    Affiliation
    Christie Hospital NHS Trust, Manchester, UK. Fiona.Blackhall@christie-tr.nwest.nhs.uk
    Issue Date
    2007-03
    
    Metadata
    Show full item record
    Abstract
    PURPOSE OF REVIEW: Small cell lung cancer is a chemosensitive malignancy, yet long-term survival remains elusive for the majority of patients. Here, we report on progress in evaluating novel targeted therapies for the treatment of this disease. RECENT FINDINGS: Interferons, matrix metalloproteinase inhibitors, thalidomide, bevacizumab, ZD6474, imatinib, gefitinib, oblimersen and aplidine have all entered clinical trial in patients with small cell lung cancer. Immunotherapy approaches targeting cell surface antigens such as CD-56 (BB10901) and GD3 ganglioside are also being evaluated. Interferons, matrix metalloproteinase inhibitors, imatinib and gefitinib have failed to demonstrate efficacy for this disease. Preliminary data for thalidomide are promising and so results from trials of other antiangiogenics such as bevacizumab and ZD6474 are awaited with interest. SUMMARY: Although the promise of targeted therapy has yet to be realized in patients with small cell lung cancer, the number of agents available for evaluation provides new optimism that progress will be made over the next decades.
    Citation
    Small cell lung cancer and targeted therapies. 2007, 19 (2):103-8 Curr Opin Oncol
    Journal
    Current Opinion in Oncology
    URI
    http://hdl.handle.net/10541/70218
    DOI
    10.1097/CCO.0b013e328011bec3
    PubMed ID
    17272981
    Type
    Article
    Language
    en
    ISSN
    1040-8746
    ae974a485f413a2113503eed53cd6c53
    10.1097/CCO.0b013e328011bec3
    Scopus Count
    Collections
    All Christie Publications

    entitlement

    Related articles

    • New targets for non-small-cell lung cancer therapy.
    • Authors: Alvarez M, Roman E, Santos ES, Raez LE
    • Issue date: 2007 Oct
    • Multitargeted inhibitors in lung cancer: new clinical data.
    • Authors: Bar J, Herbst RS, Onn A
    • Issue date: 2008
    • Targeted therapies and non-small-cell lung cancer: work in progress?
    • Authors: Gridelli C
    • Issue date: 2006 Mar
    • Beyond antiepidermal growth factor receptors and antiangiogenesis strategies for nonsmall cell lung cancer: exploring a new frontier.
    • Authors: Sangha R, Lara PN Jr, Mack PC, Gandara DR
    • Issue date: 2009 Mar
    • Antiangiogenic therapy in nonsmall cell lung cancer.
    • Authors: Gutierrez M, Giaccone G
    • Issue date: 2008 Mar
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.