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dc.contributor.authorSims, Andrew H
dc.contributor.authorHowell, Anthony
dc.contributor.authorHowell, Sacha J
dc.contributor.authorClarke, Robert B
dc.date.accessioned2009-06-11T11:32:17Z
dc.date.available2009-06-11T11:32:17Z
dc.date.issued2007-09
dc.identifier.citationOrigins of breast cancer subtypes and therapeutic implications. 2007, 4 (9):516-25 Nat Clin Pract Oncolen
dc.identifier.issn1743-4262
dc.identifier.pmid17728710
dc.identifier.doi10.1038/ncponc0908
dc.identifier.urihttp://hdl.handle.net/10541/70162
dc.description.abstractThis Review summarizes and evaluates the current evidence for the cellular origins of breast cancer subtypes identified by different approaches such as histology, molecular pathology, genetic and gene-expression analysis. Emerging knowledge of the normal breast cell types has led to the hypothesis that the subtypes of breast cancer might arise from mutations or genetic rearrangements occurring in different populations of stem cells and progenitor cells. We describe the common distinguishing features of these breast cancer subtypes and explain how these features relate both to prognosis and to selection of the most appropriate therapy. Recent data indicate that breast tumors may originate from cancer stem cells. Consequently, inhibition of stem-cell self-renewal pathways should be explored because of the likelihood that residual stem cells might be resistant to current therapies.
dc.language.isoenen
dc.subjectBreast Canceren
dc.subjectTumour Markersen
dc.subject.meshAntibodies, Monoclonal
dc.subject.meshAntineoplastic Agents
dc.subject.meshBreast Neoplasms
dc.subject.meshCell Transformation, Neoplastic
dc.subject.meshFemale
dc.subject.meshGene Expression Profiling
dc.subject.meshHumans
dc.subject.meshSelective Estrogen Receptor Modulators
dc.subject.meshStem Cells
dc.subject.meshTumor Markers, Biological
dc.titleOrigins of breast cancer subtypes and therapeutic implications.en
dc.typeArticleen
dc.contributor.departmentBreast Biology Group, Paterson Institute for Cancer Research, University of Manchester, Manchester, UK.en
dc.identifier.journalNature Clinical Practice Oncologyen
html.description.abstractThis Review summarizes and evaluates the current evidence for the cellular origins of breast cancer subtypes identified by different approaches such as histology, molecular pathology, genetic and gene-expression analysis. Emerging knowledge of the normal breast cell types has led to the hypothesis that the subtypes of breast cancer might arise from mutations or genetic rearrangements occurring in different populations of stem cells and progenitor cells. We describe the common distinguishing features of these breast cancer subtypes and explain how these features relate both to prognosis and to selection of the most appropriate therapy. Recent data indicate that breast tumors may originate from cancer stem cells. Consequently, inhibition of stem-cell self-renewal pathways should be explored because of the likelihood that residual stem cells might be resistant to current therapies.


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