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    Origins of breast cancer subtypes and therapeutic implications.

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    Authors
    Sims, Andrew H
    Howell, Anthony
    Howell, Sacha J
    Clarke, Robert B
    Affiliation
    Breast Biology Group, Paterson Institute for Cancer Research, University of Manchester, Manchester, UK.
    Issue Date
    2007-09
    
    Metadata
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    Abstract
    This Review summarizes and evaluates the current evidence for the cellular origins of breast cancer subtypes identified by different approaches such as histology, molecular pathology, genetic and gene-expression analysis. Emerging knowledge of the normal breast cell types has led to the hypothesis that the subtypes of breast cancer might arise from mutations or genetic rearrangements occurring in different populations of stem cells and progenitor cells. We describe the common distinguishing features of these breast cancer subtypes and explain how these features relate both to prognosis and to selection of the most appropriate therapy. Recent data indicate that breast tumors may originate from cancer stem cells. Consequently, inhibition of stem-cell self-renewal pathways should be explored because of the likelihood that residual stem cells might be resistant to current therapies.
    Citation
    Origins of breast cancer subtypes and therapeutic implications. 2007, 4 (9):516-25 Nat Clin Pract Oncol
    Journal
    Nature Clinical Practice Oncology
    URI
    http://hdl.handle.net/10541/70162
    DOI
    10.1038/ncponc0908
    PubMed ID
    17728710
    Type
    Article
    Language
    en
    ISSN
    1743-4262
    ae974a485f413a2113503eed53cd6c53
    10.1038/ncponc0908
    Scopus Count
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    All Christie Publications
    All Paterson Institute for Cancer Research

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