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dc.contributor.authorAlkureishi, Lee W T
dc.contributor.authorRoss, Gary L
dc.contributor.authorMacDonald, D Gordon
dc.contributor.authorShoaib, Taimur
dc.contributor.authorGray, Harry W
dc.contributor.authorRobertson, Gerry
dc.contributor.authorSoutar, David S
dc.date.accessioned2009-06-11T10:51:55Z
dc.date.available2009-06-11T10:51:55Z
dc.date.issued2007-02
dc.identifier.citationSentinel node in head and neck cancer: use of size criterion to upstage the no neck in head and neck squamous cell carcinoma. 2007, 29 (2):95-103 Head Necken
dc.identifier.issn1043-3074
dc.identifier.pmid17120312
dc.identifier.doi10.1002/hed.20486
dc.identifier.urihttp://hdl.handle.net/10541/70153
dc.description.abstractBACKGROUND: Anatomical imaging tools demonstrate poor sensitivity in head and neck squamous cell carcinoma (HNSCC) patients with clinically node-negative necks (cN0). This study evaluates nodal size as a staging criterion for detection of cervical metastases, utilizing sentinel node biopsy (SNB) and additional pathology (step-serial sectioning, SSS; and immunohistochemistry, IHC). METHODS: Sixty-five patients with clinically N0 disease underwent SNB, with a mean of 2.4 nodes excised per patient. Nodes were fixed in formalin, bisected, and measured in 3 axes before hematoxylin-eosin staining. Negative nodes were subjected to SSS and IHC. SNB-positive patients underwent modified radical neck dissection. RESULTS: Maximum diameter was larger in levels II and III (13.1 and 13.2 mm) when compared with level I (10.5 mm; p = .004, p = .018), while minimum diameter was constant. Positive nodes were larger than negative nodes (p = .007), but nodes found positive by SSS/IHC were not significantly larger than negative nodes for either measurement (p = .433). Sensitivity and specificity were poor for all measurements. CONCLUSIONS: Nodal size is an inaccurate predictor of nodal metastases and should not be regarded as an accurate means of staging the clinically N0 neck.
dc.language.isoenen
dc.subjectHead and Neck Canceren
dc.subjectCancer Stagingen
dc.subject.meshCarcinoma, Squamous Cell
dc.subject.meshHead and Neck Neoplasms
dc.subject.meshHumans
dc.subject.meshImmunohistochemistry
dc.subject.meshLymph Node Excision
dc.subject.meshLymph Nodes
dc.subject.meshNeck Dissection
dc.subject.meshNeoplasm Staging
dc.subject.meshSensitivity and Specificity
dc.subject.meshSentinel Lymph Node Biopsy
dc.titleSentinel node in head and neck cancer: use of size criterion to upstage the no neck in head and neck squamous cell carcinoma.en
dc.typeArticleen
dc.contributor.departmentPlastic Surgery Unit, Canniesburn Hospital, Glasgow Royal Infirmary, Glasgow, UK. lee_alkureishi@hotmail.comen
dc.identifier.journalHead & Necken
html.description.abstractBACKGROUND: Anatomical imaging tools demonstrate poor sensitivity in head and neck squamous cell carcinoma (HNSCC) patients with clinically node-negative necks (cN0). This study evaluates nodal size as a staging criterion for detection of cervical metastases, utilizing sentinel node biopsy (SNB) and additional pathology (step-serial sectioning, SSS; and immunohistochemistry, IHC). METHODS: Sixty-five patients with clinically N0 disease underwent SNB, with a mean of 2.4 nodes excised per patient. Nodes were fixed in formalin, bisected, and measured in 3 axes before hematoxylin-eosin staining. Negative nodes were subjected to SSS and IHC. SNB-positive patients underwent modified radical neck dissection. RESULTS: Maximum diameter was larger in levels II and III (13.1 and 13.2 mm) when compared with level I (10.5 mm; p = .004, p = .018), while minimum diameter was constant. Positive nodes were larger than negative nodes (p = .007), but nodes found positive by SSS/IHC were not significantly larger than negative nodes for either measurement (p = .433). Sensitivity and specificity were poor for all measurements. CONCLUSIONS: Nodal size is an inaccurate predictor of nodal metastases and should not be regarded as an accurate means of staging the clinically N0 neck.


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