Pulmonary lipomatous hemangiopericytoma: report of a rare tumor and comparison with solitary fibrous tumor.
AffiliationDepartment of Pathology, Saiseikai Central Hospital, Tokyo, Japan. KazutoYamazaki@aol.com
MetadataShow full item record
AbstractLipomatous hemangiopericytoma is a rare mesenchymal tumor showing areas of lipid-containing cells admixed with a spindle-cell component. Like other hemangiopericytomas, it shows a similar vascular pattern to solitary fibrous tumor and, partly for this reason, it and other hemangiopericytomas have been subsumed into solitary fibrous tumor. The present study provides a comprehensive documentation of a single case of pulmonary lipomatous hemangiopericytoma of the lung, the first to be described at this site, and compares it with solitary fibrous tumor, in terms of clinical, histological, immunohistochemical, ultrastructural, and cytogenetic findings. Apart from the lipid-laden-cell component, pulmonary lipomatous hemangiopericytoma and solitary fibrous tumor were similar histologically. Bcl-2 was positive in both. CD34 was minimally expressed in pulmonary lipomatous hemangiopericytoma, which possessed some non-descriptive intercellular junctions, a feature shared by solitary fibrous tumor, which was CD34 positive. However, one of the latter was rich in gap junctions, a feature consistent with strong connexin (Cx) 43 staining and the existence, hitherto unappreciated, of a CD34/Cx43-positive tumor cell network. In pulmonary lipomatous hemangiopericytoma, chromosomal deletions of 43-44, X, -Y were found. In solitary fibrous tumor, 46, XY, del(13)(q?) abnormalities and abnormalities involving chromosome 10 were frequently observed. These similarities and differences are discussed in the context of the currently favored diagnostic fusion of hemangiopericytoma and solitary fibrous tumor.
CitationPulmonary lipomatous hemangiopericytoma: report of a rare tumor and comparison with solitary fibrous tumor., 31 (1):51-61 Ultrastruct Pathol
- Distinction of endometrial stromal sarcomas from 'hemangiopericytomatous' tumors using a panel of immunohistochemical stains.
- Authors: Bhargava R, Shia J, Hummer AJ, Thaler HT, Tornos C, Soslow RA
- Issue date: 2005 Jan
- Lipomatous hemangiopericytoma: a fat-containing variant of solitary fibrous tumor? Clinicopathologic, immunohistochemical, and ultrastructural analysis of a series in favor of a unifying concept.
- Authors: Guillou L, Gebhard S, Coindre JM
- Issue date: 2000 Sep
- Tumor size-related DNA copy number changes occur in solitary fibrous tumors but not in hemangiopericytomas.
- Authors: Miettinen MM, el-Rifai W, Sarlomo-Rikala M, Andersson LC, Knuutila S
- Issue date: 1997 Dec
- Solitary fibrous tumor of the orbit.
- Authors: O'Donovan DA, Bilbao JM, Fazl M, Antonyshyn OM
- Issue date: 2002 Sep
- Orbital solitary fibrous tumor: encompassing terminology for hemangiopericytoma, giant cell angiofibroma, and fibrous histiocytoma of the orbit: reappraisal of 41 cases.
- Authors: Furusato E, Valenzuela IA, Fanburg-Smith JC, Auerbach A, Furusato B, Cameron JD, Rushing EJ
- Issue date: 2011 Jan