Association between serum insulin-like growth factor-I levels and thyroid disorders in a population-based study.
dc.contributor.author | Völzke, Henry | |
dc.contributor.author | Friedrich, Nele | |
dc.contributor.author | Schipf, Sabine | |
dc.contributor.author | Haring, Robin | |
dc.contributor.author | Lüdemann, Jan | |
dc.contributor.author | Nauck, Matthias | |
dc.contributor.author | Dörr, Marcus | |
dc.contributor.author | Brabant, Georg E | |
dc.contributor.author | Wallaschofski, Henri | |
dc.date.accessioned | 2009-06-09T16:38:48Z | |
dc.date.available | 2009-06-09T16:38:48Z | |
dc.date.issued | 2007-10 | |
dc.identifier.citation | Association between serum insulin-like growth factor-I levels and thyroid disorders in a population-based study. 2007, 92 (10):4039-45 J. Clin. Endocrinol. Metab. | en |
dc.identifier.issn | 0021-972X | |
dc.identifier.pmid | 17666480 | |
dc.identifier.doi | 10.1210/jc.2007-0816 | |
dc.identifier.uri | http://hdl.handle.net/10541/70039 | |
dc.description.abstract | OBJECTIVE: There is current debate on whether serum IGF-I levels are associated with thyroid disorders. The aims of the present study were: 1) to investigate possible associations between serum IGF-I levels and thyroid disorders and 2) to analyze the role of serum IGF binding protein (IGFBP)-3 and TSH levels for these associations. DESIGN: This was a cross-sectional Study of Health in Pomerania. SETTING: The study was conducted in the general population of northeast Germany. Subjects: The study population comprised 3662 subjects (1746 women) without history of thyroid disorders. INTERVENTIONS: No interventions have been performed. MAIN OUTCOME MEASURES: Goiter and thyroid nodules were determined by ultrasound. Serum TSH levels less than 0.25 mIU/liter were considered decreased. RESULTS: Adjusted for major confounders and risk factors for thyroid disorders, subjects with serum IGF-I levels above the upper tertile had higher odds for goiter relative to subjects with serum IGF-I levels below the lower tertile [odds ratio (OR) 1.67; 95% confidence interval (CI) 1.24-2.26 in women; OR 2.04; 95% CI 1.55-2.68 in men]. A similar association was present for thyroid nodules in men (OR 1.64; 95% CI 1.17-2.32) and for decreased serum TSH levels in women (OR 1.65; 95% CI 1.00-2.69). Serum IGFBP-3 levels were not associated with thyroid disorders and did not represent effect modifiers for the association between serum IGF-I levels and the endpoints. CONCLUSIONS: We conclude that high serum IGF-I levels are associated with goiter. Whereas high serum IGF-I levels are also related to thyroid nodules in men, they are related to decreased serum TSH levels in women. Serum IGFBP-3 and TSH levels did not modulate these associations. | |
dc.language.iso | en | en |
dc.subject.mesh | Adult | |
dc.subject.mesh | Aged | |
dc.subject.mesh | Cross-Sectional Studies | |
dc.subject.mesh | Female | |
dc.subject.mesh | Germany | |
dc.subject.mesh | Goiter | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Insulin-Like Growth Factor Binding Proteins | |
dc.subject.mesh | Insulin-Like Growth Factor I | |
dc.subject.mesh | Male | |
dc.subject.mesh | Middle Aged | |
dc.subject.mesh | Risk Factors | |
dc.subject.mesh | Sex Distribution | |
dc.subject.mesh | Thyroid Nodule | |
dc.subject.mesh | Thyrotropin | |
dc.title | Association between serum insulin-like growth factor-I levels and thyroid disorders in a population-based study. | en |
dc.type | Article | en |
dc.contributor.department | Institute of Community Medicine, University of Greifswald, D-17487 Greifswald, Germany. voelzke@uni-greifswald.de | en |
dc.identifier.journal | The Journal of Clinical Endocrinology and Metabolism | en |
html.description.abstract | OBJECTIVE: There is current debate on whether serum IGF-I levels are associated with thyroid disorders. The aims of the present study were: 1) to investigate possible associations between serum IGF-I levels and thyroid disorders and 2) to analyze the role of serum IGF binding protein (IGFBP)-3 and TSH levels for these associations. DESIGN: This was a cross-sectional Study of Health in Pomerania. SETTING: The study was conducted in the general population of northeast Germany. Subjects: The study population comprised 3662 subjects (1746 women) without history of thyroid disorders. INTERVENTIONS: No interventions have been performed. MAIN OUTCOME MEASURES: Goiter and thyroid nodules were determined by ultrasound. Serum TSH levels less than 0.25 mIU/liter were considered decreased. RESULTS: Adjusted for major confounders and risk factors for thyroid disorders, subjects with serum IGF-I levels above the upper tertile had higher odds for goiter relative to subjects with serum IGF-I levels below the lower tertile [odds ratio (OR) 1.67; 95% confidence interval (CI) 1.24-2.26 in women; OR 2.04; 95% CI 1.55-2.68 in men]. A similar association was present for thyroid nodules in men (OR 1.64; 95% CI 1.17-2.32) and for decreased serum TSH levels in women (OR 1.65; 95% CI 1.00-2.69). Serum IGFBP-3 levels were not associated with thyroid disorders and did not represent effect modifiers for the association between serum IGF-I levels and the endpoints. CONCLUSIONS: We conclude that high serum IGF-I levels are associated with goiter. Whereas high serum IGF-I levels are also related to thyroid nodules in men, they are related to decreased serum TSH levels in women. Serum IGFBP-3 and TSH levels did not modulate these associations. |