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dc.contributor.authorVölzke, Henry
dc.contributor.authorFriedrich, Nele
dc.contributor.authorSchipf, Sabine
dc.contributor.authorHaring, Robin
dc.contributor.authorLüdemann, Jan
dc.contributor.authorNauck, Matthias
dc.contributor.authorDörr, Marcus
dc.contributor.authorBrabant, Georg E
dc.contributor.authorWallaschofski, Henri
dc.date.accessioned2009-06-09T16:38:48Z
dc.date.available2009-06-09T16:38:48Z
dc.date.issued2007-10
dc.identifier.citationAssociation between serum insulin-like growth factor-I levels and thyroid disorders in a population-based study. 2007, 92 (10):4039-45 J. Clin. Endocrinol. Metab.en
dc.identifier.issn0021-972X
dc.identifier.pmid17666480
dc.identifier.doi10.1210/jc.2007-0816
dc.identifier.urihttp://hdl.handle.net/10541/70039
dc.description.abstractOBJECTIVE: There is current debate on whether serum IGF-I levels are associated with thyroid disorders. The aims of the present study were: 1) to investigate possible associations between serum IGF-I levels and thyroid disorders and 2) to analyze the role of serum IGF binding protein (IGFBP)-3 and TSH levels for these associations. DESIGN: This was a cross-sectional Study of Health in Pomerania. SETTING: The study was conducted in the general population of northeast Germany. Subjects: The study population comprised 3662 subjects (1746 women) without history of thyroid disorders. INTERVENTIONS: No interventions have been performed. MAIN OUTCOME MEASURES: Goiter and thyroid nodules were determined by ultrasound. Serum TSH levels less than 0.25 mIU/liter were considered decreased. RESULTS: Adjusted for major confounders and risk factors for thyroid disorders, subjects with serum IGF-I levels above the upper tertile had higher odds for goiter relative to subjects with serum IGF-I levels below the lower tertile [odds ratio (OR) 1.67; 95% confidence interval (CI) 1.24-2.26 in women; OR 2.04; 95% CI 1.55-2.68 in men]. A similar association was present for thyroid nodules in men (OR 1.64; 95% CI 1.17-2.32) and for decreased serum TSH levels in women (OR 1.65; 95% CI 1.00-2.69). Serum IGFBP-3 levels were not associated with thyroid disorders and did not represent effect modifiers for the association between serum IGF-I levels and the endpoints. CONCLUSIONS: We conclude that high serum IGF-I levels are associated with goiter. Whereas high serum IGF-I levels are also related to thyroid nodules in men, they are related to decreased serum TSH levels in women. Serum IGFBP-3 and TSH levels did not modulate these associations.
dc.language.isoenen
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshCross-Sectional Studies
dc.subject.meshFemale
dc.subject.meshGermany
dc.subject.meshGoiter
dc.subject.meshHumans
dc.subject.meshInsulin-Like Growth Factor Binding Proteins
dc.subject.meshInsulin-Like Growth Factor I
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshRisk Factors
dc.subject.meshSex Distribution
dc.subject.meshThyroid Nodule
dc.subject.meshThyrotropin
dc.titleAssociation between serum insulin-like growth factor-I levels and thyroid disorders in a population-based study.en
dc.typeArticleen
dc.contributor.departmentInstitute of Community Medicine, University of Greifswald, D-17487 Greifswald, Germany. voelzke@uni-greifswald.deen
dc.identifier.journalThe Journal of Clinical Endocrinology and Metabolismen
html.description.abstractOBJECTIVE: There is current debate on whether serum IGF-I levels are associated with thyroid disorders. The aims of the present study were: 1) to investigate possible associations between serum IGF-I levels and thyroid disorders and 2) to analyze the role of serum IGF binding protein (IGFBP)-3 and TSH levels for these associations. DESIGN: This was a cross-sectional Study of Health in Pomerania. SETTING: The study was conducted in the general population of northeast Germany. Subjects: The study population comprised 3662 subjects (1746 women) without history of thyroid disorders. INTERVENTIONS: No interventions have been performed. MAIN OUTCOME MEASURES: Goiter and thyroid nodules were determined by ultrasound. Serum TSH levels less than 0.25 mIU/liter were considered decreased. RESULTS: Adjusted for major confounders and risk factors for thyroid disorders, subjects with serum IGF-I levels above the upper tertile had higher odds for goiter relative to subjects with serum IGF-I levels below the lower tertile [odds ratio (OR) 1.67; 95% confidence interval (CI) 1.24-2.26 in women; OR 2.04; 95% CI 1.55-2.68 in men]. A similar association was present for thyroid nodules in men (OR 1.64; 95% CI 1.17-2.32) and for decreased serum TSH levels in women (OR 1.65; 95% CI 1.00-2.69). Serum IGFBP-3 levels were not associated with thyroid disorders and did not represent effect modifiers for the association between serum IGF-I levels and the endpoints. CONCLUSIONS: We conclude that high serum IGF-I levels are associated with goiter. Whereas high serum IGF-I levels are also related to thyroid nodules in men, they are related to decreased serum TSH levels in women. Serum IGFBP-3 and TSH levels did not modulate these associations.


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