Association between serum insulin-like growth factor-I levels and thyroid disorders in a population-based study.
Authors
Völzke, HenryFriedrich, Nele
Schipf, Sabine
Haring, Robin
Lüdemann, Jan
Nauck, Matthias
Dörr, Marcus
Brabant, Georg E
Wallaschofski, Henri
Affiliation
Institute of Community Medicine, University of Greifswald, D-17487 Greifswald, Germany. voelzke@uni-greifswald.deIssue Date
2007-10
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OBJECTIVE: There is current debate on whether serum IGF-I levels are associated with thyroid disorders. The aims of the present study were: 1) to investigate possible associations between serum IGF-I levels and thyroid disorders and 2) to analyze the role of serum IGF binding protein (IGFBP)-3 and TSH levels for these associations. DESIGN: This was a cross-sectional Study of Health in Pomerania. SETTING: The study was conducted in the general population of northeast Germany. Subjects: The study population comprised 3662 subjects (1746 women) without history of thyroid disorders. INTERVENTIONS: No interventions have been performed. MAIN OUTCOME MEASURES: Goiter and thyroid nodules were determined by ultrasound. Serum TSH levels less than 0.25 mIU/liter were considered decreased. RESULTS: Adjusted for major confounders and risk factors for thyroid disorders, subjects with serum IGF-I levels above the upper tertile had higher odds for goiter relative to subjects with serum IGF-I levels below the lower tertile [odds ratio (OR) 1.67; 95% confidence interval (CI) 1.24-2.26 in women; OR 2.04; 95% CI 1.55-2.68 in men]. A similar association was present for thyroid nodules in men (OR 1.64; 95% CI 1.17-2.32) and for decreased serum TSH levels in women (OR 1.65; 95% CI 1.00-2.69). Serum IGFBP-3 levels were not associated with thyroid disorders and did not represent effect modifiers for the association between serum IGF-I levels and the endpoints. CONCLUSIONS: We conclude that high serum IGF-I levels are associated with goiter. Whereas high serum IGF-I levels are also related to thyroid nodules in men, they are related to decreased serum TSH levels in women. Serum IGFBP-3 and TSH levels did not modulate these associations.Citation
Association between serum insulin-like growth factor-I levels and thyroid disorders in a population-based study. 2007, 92 (10):4039-45 J. Clin. Endocrinol. Metab.Journal
The Journal of Clinical Endocrinology and MetabolismDOI
10.1210/jc.2007-0816PubMed ID
17666480Type
ArticleLanguage
enISSN
0021-972Xae974a485f413a2113503eed53cd6c53
10.1210/jc.2007-0816
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