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dc.contributor.authorHoureih, Mohammad Adib
dc.contributor.authorLin, Amy Y
dc.contributor.authorEyden, Brian P
dc.contributor.authorMenasce, Lia P
dc.contributor.authorHarrison, James
dc.contributor.authorJones, David R
dc.contributor.authorFolberg, Robert
dc.contributor.authorChejfec, Gregorio
dc.contributor.authorBanerjee, Saumitra S
dc.date.accessioned2009-06-05T10:15:34Z
dc.date.available2009-06-05T10:15:34Z
dc.date.issued2009-04
dc.identifier.citationAlveolar rhabdomyosarcoma with neuroendocrine/neuronal differentiation: report of 3 cases. 2009, 17 (2):135-41 Int. J. Surg. Pathol.en
dc.identifier.issn1066-8969
dc.identifier.pmid18611935
dc.identifier.doi10.1177/1066896908319444
dc.identifier.urihttp://hdl.handle.net/10541/69766
dc.description.abstractThe aim of this study is to report the clinicopathologic characteristics of 3 cases of alveolar rhabdomyosarcoma with neuroendocrine/neuronal differentiation. Specimens of 3 cases of alveolar rhabdomyosarcoma were studied using histologic, immunohistochemical, ultrastructural, and molecular genetic techniques. The patients were a 19-year-old man with metastatic alveolar rhabdomyosarcoma in a groin lymph node, a 16-year-old girl with alveolar rhabdomyosarcoma of the perineum, and a 20-year-old man with recurrent orbital alveolar rhabdomyosarcoma. Microscopically, case 1 was composed of compact sheets of medium to large tumor cells. Cases 2 and 3 were small blue round cell tumors. Cases 1 and 3 were solid throughout, whereas case 2 demonstrated alveolar and solid architecture. By immunohistochemistry, the following markers were positive: desmin (3/3), myogenin (3/3), synaptophysin (3/3), and chromogranin (2/3). Ultrastructurally, sarcomeric filaments were seen in all cases, while neuroendocrine granules were detected only in case 1. PAX:FKHR fusion transcript was identified in case 2, case 3 had a variant PAX3 transcript, and case 1 was negative. The data presented expands the known differentiation of alveolar rhabdomyosarcoma.
dc.language.isoenen
dc.subjectEye Canceren
dc.subjectOrbital Canceren
dc.subjectGenital Canceren
dc.subjectTumour Markersen
dc.subject.meshAdolescent
dc.subject.meshCell Differentiation
dc.subject.meshChromogranins
dc.subject.meshDesmin
dc.subject.meshFemale
dc.subject.meshGenital Neoplasms, Female
dc.subject.meshHumans
dc.subject.meshLymphoma
dc.subject.meshMale
dc.subject.meshMyogenin
dc.subject.meshNeuroendocrine Cells
dc.subject.meshNeurons
dc.subject.meshOrbital Neoplasms
dc.subject.meshRhabdomyosarcoma, Alveolar
dc.subject.meshSynaptophysin
dc.subject.meshTumor Markers, Biological
dc.subject.meshYoung Adult
dc.titleAlveolar rhabdomyosarcoma with neuroendocrine/neuronal differentiation: report of 3 cases.en
dc.typeArticleen
dc.contributor.departmentDepartment of Histopathology, Christie Hospital NHS Foundation Trust, Manchester, United Kingdom.en
dc.identifier.journalInternational Journal of Surgical Pathologyen
html.description.abstractThe aim of this study is to report the clinicopathologic characteristics of 3 cases of alveolar rhabdomyosarcoma with neuroendocrine/neuronal differentiation. Specimens of 3 cases of alveolar rhabdomyosarcoma were studied using histologic, immunohistochemical, ultrastructural, and molecular genetic techniques. The patients were a 19-year-old man with metastatic alveolar rhabdomyosarcoma in a groin lymph node, a 16-year-old girl with alveolar rhabdomyosarcoma of the perineum, and a 20-year-old man with recurrent orbital alveolar rhabdomyosarcoma. Microscopically, case 1 was composed of compact sheets of medium to large tumor cells. Cases 2 and 3 were small blue round cell tumors. Cases 1 and 3 were solid throughout, whereas case 2 demonstrated alveolar and solid architecture. By immunohistochemistry, the following markers were positive: desmin (3/3), myogenin (3/3), synaptophysin (3/3), and chromogranin (2/3). Ultrastructurally, sarcomeric filaments were seen in all cases, while neuroendocrine granules were detected only in case 1. PAX:FKHR fusion transcript was identified in case 2, case 3 had a variant PAX3 transcript, and case 1 was negative. The data presented expands the known differentiation of alveolar rhabdomyosarcoma.


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