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    Alveolar rhabdomyosarcoma with neuroendocrine/neuronal differentiation: report of 3 cases.

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    Authors
    Houreih, Mohammad Adib
    Lin, Amy Y
    Eyden, Brian P
    Menasce, Lia P
    Harrison, James
    Jones, David R
    Folberg, Robert
    Chejfec, Gregorio
    Banerjee, Saumitra S
    Affiliation
    Department of Histopathology, Christie Hospital NHS Foundation Trust, Manchester, United Kingdom.
    Issue Date
    2009-04
    
    Metadata
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    Abstract
    The aim of this study is to report the clinicopathologic characteristics of 3 cases of alveolar rhabdomyosarcoma with neuroendocrine/neuronal differentiation. Specimens of 3 cases of alveolar rhabdomyosarcoma were studied using histologic, immunohistochemical, ultrastructural, and molecular genetic techniques. The patients were a 19-year-old man with metastatic alveolar rhabdomyosarcoma in a groin lymph node, a 16-year-old girl with alveolar rhabdomyosarcoma of the perineum, and a 20-year-old man with recurrent orbital alveolar rhabdomyosarcoma. Microscopically, case 1 was composed of compact sheets of medium to large tumor cells. Cases 2 and 3 were small blue round cell tumors. Cases 1 and 3 were solid throughout, whereas case 2 demonstrated alveolar and solid architecture. By immunohistochemistry, the following markers were positive: desmin (3/3), myogenin (3/3), synaptophysin (3/3), and chromogranin (2/3). Ultrastructurally, sarcomeric filaments were seen in all cases, while neuroendocrine granules were detected only in case 1. PAX:FKHR fusion transcript was identified in case 2, case 3 had a variant PAX3 transcript, and case 1 was negative. The data presented expands the known differentiation of alveolar rhabdomyosarcoma.
    Citation
    Alveolar rhabdomyosarcoma with neuroendocrine/neuronal differentiation: report of 3 cases. 2009, 17 (2):135-41 Int. J. Surg. Pathol.
    Journal
    International Journal of Surgical Pathology
    URI
    http://hdl.handle.net/10541/69766
    DOI
    10.1177/1066896908319444
    PubMed ID
    18611935
    Type
    Article
    Language
    en
    ISSN
    1066-8969
    ae974a485f413a2113503eed53cd6c53
    10.1177/1066896908319444
    Scopus Count
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    All Christie Publications
    Pathology

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