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    Fibronexus junctions associated with in vivo human endothelium.

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    Authors
    Eyden, Brian P
    Affiliation
    Department of Histopathology, The Christie NHS Foundation Trust, Manchester, UK. brian.eyden@christie.nhs.uk
    Issue Date
    2009
    
    Metadata
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    Abstract
    The fibronexus is recognized as a characteristic marker of the myofibroblast. However, it is not completely specific for this cell, having been seen in aortic smooth muscle (in attenuated form) and endothelium in experimental animals. This paper documents fibronexus junctions in human in vivo endothelium. Ultrastructural observations were made on the vasculature of a desmoplastic and focally neurotropic malignant melanoma. Cross-sectioned fibronectin fibrils were seen outside the stromal surface of the endothelial plasmalemma. Often, they were positioned directly opposite the actin-filament bundles in the peripheral cytoplasm. Neoplastic and in vitro cultured cells apart, endothelium is the only nonmyofibroblastic cell type to show well-developed fibronexus junctions. Mostly, they have been documented in aortic endothelium in experimental animals, where they possibly constitute an adaptation to hemodynamic stress, and where they might more securely anchor endothelium on to subjacent connective tissue. They might also function as mechanotransducers of extracellular stress in the extracellular milieu. The present observations constitute a further, rare example of endothelium-associated fibronexuses in reactive human vessels.
    Citation
    Fibronexus junctions associated with in vivo human endothelium., 33 (1):28-32 Ultrastruct Pathol
    Journal
    Ultrastructural Pathology
    URI
    http://hdl.handle.net/10541/69764
    DOI
    10.1080/01913120802625822
    PubMed ID
    19191199
    Type
    Article
    Language
    en
    ISSN
    1521-0758
    ae974a485f413a2113503eed53cd6c53
    10.1080/01913120802625822
    Scopus Count
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    All Christie Publications
    Pathology

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