Authors
Eyden, Brian PAffiliation
Department of Histopathology, The Christie NHS Foundation Trust, Manchester, UK. brian.eyden@christie.nhs.ukIssue Date
2009
Metadata
Show full item recordAbstract
The fibronexus is recognized as a characteristic marker of the myofibroblast. However, it is not completely specific for this cell, having been seen in aortic smooth muscle (in attenuated form) and endothelium in experimental animals. This paper documents fibronexus junctions in human in vivo endothelium. Ultrastructural observations were made on the vasculature of a desmoplastic and focally neurotropic malignant melanoma. Cross-sectioned fibronectin fibrils were seen outside the stromal surface of the endothelial plasmalemma. Often, they were positioned directly opposite the actin-filament bundles in the peripheral cytoplasm. Neoplastic and in vitro cultured cells apart, endothelium is the only nonmyofibroblastic cell type to show well-developed fibronexus junctions. Mostly, they have been documented in aortic endothelium in experimental animals, where they possibly constitute an adaptation to hemodynamic stress, and where they might more securely anchor endothelium on to subjacent connective tissue. They might also function as mechanotransducers of extracellular stress in the extracellular milieu. The present observations constitute a further, rare example of endothelium-associated fibronexuses in reactive human vessels.Citation
Fibronexus junctions associated with in vivo human endothelium., 33 (1):28-32 Ultrastruct PatholJournal
Ultrastructural PathologyDOI
10.1080/01913120802625822PubMed ID
19191199Type
ArticleLanguage
enISSN
1521-0758ae974a485f413a2113503eed53cd6c53
10.1080/01913120802625822
Scopus Count
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