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    Failure of antibody response to polysaccharide antigen in treated panhypopituitary adults.

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    Authors
    Mukherjee, Annice
    Helbert, M
    Ryder, W David J
    Borrow, R
    Davis, Julian R E
    Shalet, Stephen M
    Affiliation
    Department of Endocrinology, Christie Hospital, Manchester, UK. annice.mukherjee@srht.nhs.uk
    Issue Date
    2009-05
    
    Metadata
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    Abstract
    Although pituitary hormones are known to affect immune function, treated hypopituitarism is not a recognized cause of immune deficiency in humans. We set out to assess integrity of baseline and stimulated immune function in severely hypopituitary adults. Twenty-one panhypopituitary adults (group 1), on stable pituitary replacement including growth hormone, and 12 healthy volunteers (group 2) were studied. Lymphocyte subsets, pneumococcal antibody levels pre- and 1 month after polysaccharide vaccination, T cell numbers and in-vitro interferon (IFN)-gamma response were studied. There were no significant differences in T cell numbers or IFN-gamma secretion. B cell numbers were lower in group 1, especially those with low prolactin levels. Independent of this finding, nine of 21 patients in this group had low antibody response to polysaccharide antigen. This was most striking in those with low insulin-like growth factor 1 levels and appeared to be independent of the use of anti-convulsants or corticosteroid replacement. Significant humoral immune deficiency is seen in panhypopituitarism and may contribute to morbidity.
    Citation
    Failure of antibody response to polysaccharide antigen in treated panhypopituitary adults. 2009, 156 (2):271-7 Clin. Exp. Immunol.
    Journal
    Clinical and Experimental Immunology
    URI
    http://hdl.handle.net/10541/69761
    DOI
    10.1111/j.1365-2249.2009.03881.x
    PubMed ID
    19236430
    Type
    Article
    Language
    en
    ISSN
    1365-2249
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-2249.2009.03881.x
    Scopus Count
    Collections
    All Christie Publications
    Endocrinology

    entitlement

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