Ultrasound Imaging to Assess Inter- and Intra-fraction Motion during Bladder Radiotherapy and its Potential as a Verification Tool.
dc.contributor.author | McBain, Catherine A | |
dc.contributor.author | Green, M M | |
dc.contributor.author | Stratford, Julia | |
dc.contributor.author | Davies, Julie | |
dc.contributor.author | McCarthy, Claire | |
dc.contributor.author | Taylor, Benjamin | |
dc.contributor.author | McHugh, D | |
dc.contributor.author | Swindell, Ric | |
dc.contributor.author | Khoo, Vincent S | |
dc.contributor.author | Price, Patricia M | |
dc.date.accessioned | 2009-06-04T14:38:05Z | |
dc.date.available | 2009-06-04T14:38:05Z | |
dc.date.issued | 2009-06 | |
dc.identifier.citation | Ultrasound Imaging to Assess Inter- and Intra-fraction Motion during Bladder Radiotherapy and its Potential as a Verification Tool. 2009, 21 (5):385-93 Clin Oncol | en |
dc.identifier.issn | 0936-6555 | |
dc.identifier.pmid | 19282158 | |
dc.identifier.doi | 10.1016/j.clon.2009.01.016 | |
dc.identifier.uri | http://hdl.handle.net/10541/69738 | |
dc.description.abstract | AIMS: Organ motion is the principle source of error in bladder cancer radiotherapy. The aim of this study was to evaluate ultrasound bladder volume measurement as a surrogate measure of organ motion during radiotherapy: (1) to assess inter- and intra-fraction bladder variation and (2) as a potential treatment verification tool. MATERIALS AND METHODS: Twenty patients receiving radical radiotherapy for bladder cancer underwent post-void ultrasound bladder volume measurement at the time of radiotherapy treatment planning (RTP), and immediately before (post-void) and after receiving daily fractions. RESULTS: Ultrasound bladder volume measurement was found to be a simple and acceptable method to estimate relative bladder volume changes. Six patients showed significant changes to post-void bladder volume over the treatment course (P<0.05). The mean inter-fraction post-void bladder volume of five patients exceeded their RTP ultrasound bladder volume by more than 50%. Intra-fraction bladder volume increased on 275/308 (89%) assessed fractions, with the mean intra-fraction volume increases of seven patients exceeding their RTP ultrasound bladder volume by more than 50%. CONCLUSIONS: Both day-to-day bladder volume variation and bladder filling during treatment should be considered in RTP and delivery. Ultrasound may provide a practical daily verification tool by: supporting volume limitation as a method of treatment margin reduction; allowing detection of patients who may require interventions to promote bladder reproducibility; and identifying patients with prominent volume changes for the selective application of more advanced adaptive/image-guided radiotherapy techniques. | |
dc.language.iso | en | en |
dc.subject | Bladder Motion | en |
dc.subject | Radiotherapy | en |
dc.subject | Ultrasound Imaging | en |
dc.subject | Verification | en |
dc.title | Ultrasound Imaging to Assess Inter- and Intra-fraction Motion during Bladder Radiotherapy and its Potential as a Verification Tool. | en |
dc.type | Article | en |
dc.contributor.department | Academic Department of Radiation Oncology, Christie Hospital NHS Trust, Manchester, UK. | en |
dc.identifier.journal | Clinical Oncology | en |
html.description.abstract | AIMS: Organ motion is the principle source of error in bladder cancer radiotherapy. The aim of this study was to evaluate ultrasound bladder volume measurement as a surrogate measure of organ motion during radiotherapy: (1) to assess inter- and intra-fraction bladder variation and (2) as a potential treatment verification tool. MATERIALS AND METHODS: Twenty patients receiving radical radiotherapy for bladder cancer underwent post-void ultrasound bladder volume measurement at the time of radiotherapy treatment planning (RTP), and immediately before (post-void) and after receiving daily fractions. RESULTS: Ultrasound bladder volume measurement was found to be a simple and acceptable method to estimate relative bladder volume changes. Six patients showed significant changes to post-void bladder volume over the treatment course (P<0.05). The mean inter-fraction post-void bladder volume of five patients exceeded their RTP ultrasound bladder volume by more than 50%. Intra-fraction bladder volume increased on 275/308 (89%) assessed fractions, with the mean intra-fraction volume increases of seven patients exceeding their RTP ultrasound bladder volume by more than 50%. CONCLUSIONS: Both day-to-day bladder volume variation and bladder filling during treatment should be considered in RTP and delivery. Ultrasound may provide a practical daily verification tool by: supporting volume limitation as a method of treatment margin reduction; allowing detection of patients who may require interventions to promote bladder reproducibility; and identifying patients with prominent volume changes for the selective application of more advanced adaptive/image-guided radiotherapy techniques. |
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