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    Preoperative neo-adjuvant therapy for curable rectal cancer--reaching a consensus 2008.

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    Authors
    Scott, N A
    Susnerwala, Shabbir
    Gollins, Simon W
    Myint, A Sun
    Levine, Edward
    Affiliation
    Department of Colorectal Surgery, Lancashire Teaching Hospital Trust, Preston, UK. nigel.scott@lthtr.nhs.uk
    Issue Date
    2009-03
    
    Metadata
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    Abstract
    OBJECTIVE: Our aim was to determine the range of neo-adjuvant therapy the multidisciplinary team (MDT) currently offers patients with curable (M(0)) rectal cancer. METHOD: A senior oncologist from each of the four oncology centres in north Wales and the north-west of England (approximate target population 8 million - Glan Clwyd, Clatterbridge, Christie and Preston) reviewed his/her understanding of the current evidence of neo-adjuvant therapy in rectal cancer. Then a representative from each centre was asked to identify which of three neo-adjuvant options (no neo-adjuvant therapy, short-course radiotherapy 25 Gy over five fractions and long-course chemoradiotherapy) he/she would use for a rectal cancer in the upper, middle or lower third of the rectum staged by magnetic resonance imaging as being T(2)-T(4) and/or N(0)-N(2). RESULTS: In all cases of locally advanced rectal cancer (T(3a) N(1)-T(4)), oncologists from the four oncology centres recommended long-course chemoradiotherapy before rectal resection. This consensus was maintained for cases of lower third T(3a) N(0) cancers. Thereafter, the majority of patients with rectal cancer are offered adjuvant short-course radiotherapy. CONCLUSION: Neo-adjuvant therapy is less likely to be offered if the tumour is early (T(2), N(0)) and/or situated in the upper third of the rectum.
    Citation
    Preoperative neo-adjuvant therapy for curable rectal cancer--reaching a consensus 2008. 2009, 11 (3):245-8 Colorectal Dis
    Journal
    Colorectal Disease
    URI
    http://hdl.handle.net/10541/69594
    DOI
    10.1111/j.1463-1318.2008.01636.x
    PubMed ID
    18637934
    Type
    Article
    Language
    en
    ISSN
    1463-1318
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1463-1318.2008.01636.x
    Scopus Count
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    All Christie Publications
    Clinical Oncology

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