• Cancer at ages 15-29 years: the contrasting incidence in India and England.

      Arora, R; Alston, R; Eden, Tim O B; Moran, Anthony; Geraci, M; O'Hara, Catherine; Birch, J; Cancer Research UK Paediatric and Familial Cancer Research Group, University of Manchester, Manchester, UK. reemaraman@doctors.org.uk (2012-01)
      There has been a steady increase in published research from Europe and North America on the epidemiology of cancers in young people. There are limited data from the developing world. We contrast the incidence of cancer at ages 15-29 years in India and England.
    • Changes in cancer incidence in teenagers and young adults (ages 13 to 24 years) in England 1979-2003.

      Alston, Robert D; Geraci, Marco; Eden, Tim O B; Moran, Anthony; Rowan, Steve; Birch, Jillian M; Cancer Research UK Pediatric and Familial Cancer Research Group, Royal Manchester Children's Hospital, University of Manchester, Stancliffe, Manchester, United Kingdom. robert.d.alston@manchester.ac.uk (2008-11-15)
      BACKGROUND: Cancer for teenagers and young adults represents a major source of morbidity and mortality. Trends in cancer incidence can provide pointers concerning how changes in the environment and in personal behavior affect cancer risks. METHODS: Data on 39,129 neoplasms in individuals ages 13 to 24 years who were diagnosed in England from 1979 to 2003 were analyzed. Variability in incidence by time period and differences in the time trends by age group, sex, and geographic region were analyzed using generalized linear models. RESULTS: Incidence rates of leukemias, lymphomas, central nervous system, bone, and germ cell tumors; melanoma; and carcinomas of the thyroid, ovary, cervix, and colon/rectum increased over time (all P < .01); whereas the incidence of carcinomas of the stomach and bladder decreased (both P < .01). These changes were consistent by age, sex, and region for most neoplasms. Melanoma incidence stabilized in southern England by 1993 but continued to increase in northern England (P = .001). The increase in non-Hodgkin lymphoma was greater in individuals ages 20 to 24 year than in younger individuals, but the increase in Hodgkin lymphoma was confined to individuals ages 13 to 14 years. CONCLUSIONS: The changes in incidence rates may have been caused in part by environmental changes and in part by behavioral changes in young individuals. Some of these results can be used to inform public health campaigns, which can be constructed to encourage better lifestyle choices by young individuals.
    • High cancer mortality rates in the elderly in the UK.

      Moller, Holger; Flatt, Gavin; Moran, Anthony; North West Cancer Intelligence Service, Christie NHS Foundation Trust, 63-65 Palatine Road, Manchester M20 3LJ, United Kingdom. (2011-10)
      Cancer is largely a disease of older individuals. We compared UK cancer mortality rates with those for other countries to assess progress.