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    A20 deletion is associated with copy number gain at the TNFA/B/C locus and occurs preferentially in translocation-negative MALT lymphoma of the ocular adnexa and salivary glands.

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    Authors
    Chanudet, E
    Ye, Hongtao
    Ferry, J
    Bacon, C M
    Adam, P
    Müller-Hermelink, H K
    Radford, John A
    Pileri, S A
    Ichimura, K
    Collins, V P
    Hamoudi, Rifat A
    Nicholson, Andrew G
    Wotherspoon, A C
    Isaacson, Peter G
    Du, Ming-Qing
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    Affiliation
    Division of Molecular Histopathology, Department of Pathology, University of Cambridge, UK.
    Issue Date
    2009-02
    
    Metadata
    Show full item record
    Abstract
    The genetic basis of MALT lymphoma is largely unknown. Characteristic chromosomal translocations are frequently associated with gastric and pulmonary cases, but are rare at other sites. We compared the genetic profiles of 33 ocular adnexal and 25 pulmonary MALT lymphomas by 1 Mb array-comparative genomic hybridization (CGH) and revealed recurrent 6q23 losses and 6p21.2-6p22.1 gains exclusive to ocular cases. High-resolution chromosome 6 tile-path array-CGH identified NF-kappaB inhibitor A20 as the target of 6q23.3 deletion and TNFA/B/C locus as a putative target of 6p21.2-22.1 gain. Interphase fluorescence in situ hybridization showed that A20 deletion occurred in MALT lymphoma of the ocular adnexa (8/42=19%), salivary gland (2/24=8%), thyroid (1/9=11%) and liver (1/2), but not in the lung (26), stomach (45) and skin (13). Homozygous deletion was observed in three cases. A20 deletion and TNFA/B/C gain were significantly associated (p<0.001) and exclusively found in cases without characteristic translocation. In ocular cases, A20 deletion was associated with concurrent involvement of different adnexal tissues or extraocular sites at diagnosis (p=0.007), a higher proportion of relapse (67% versus 37%) and a shorter relapse-free survival (p=0.033). A20 deletion and gain at TNFA/B/C locus may thus play an important role in the development of translocation-negative MALT lymphoma.
    Citation
    A20 deletion is associated with copy number gain at the TNFA/B/C locus and occurs preferentially in translocation-negative MALT lymphoma of the ocular adnexa and salivary glands. 2009, 217 (3):420-30 J. Pathol.
    Journal
    The Journal of Pathology
    URI
    http://hdl.handle.net/10541/69558
    DOI
    10.1002/path.2466
    PubMed ID
    19006194
    Type
    Article
    Language
    en
    ISSN
    1096-9896
    ae974a485f413a2113503eed53cd6c53
    10.1002/path.2466
    Scopus Count
    Collections
    All Christie Publications
    Medical Oncology

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