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dc.contributor.authorEvans, D Gareth R
dc.contributor.authorBaildam, Andrew D
dc.contributor.authorAnderson, Elizabeth
dc.contributor.authorBrain, Anne
dc.contributor.authorShenton, Andrew
dc.contributor.authorVasen, H F A
dc.contributor.authorEccles, Diana
dc.contributor.authorLucassen, A
dc.contributor.authorPichert, G
dc.contributor.authorHamed, H
dc.contributor.authorMoller, P
dc.contributor.authorMaehle, Lovise
dc.contributor.authorMorrison, P J
dc.contributor.authorStoppa-Lyonnet, D
dc.contributor.authorGregory, H
dc.contributor.authorSmyth, E
dc.contributor.authorNiederacher, Dieter
dc.contributor.authorNestle-Krämling, C
dc.contributor.authorCampbell, J
dc.contributor.authorHopwood, Penelope
dc.contributor.authorLalloo, Fiona
dc.contributor.authorHowell, Anthony
dc.date.accessioned2009-06-02T11:56:31Z
dc.date.available2009-06-02T11:56:31Z
dc.date.issued2009-04
dc.identifier.citationRisk reducing mastectomy: outcomes in 10 European centres. 2009, 46 (4):254-8 J. Med. Genet.en
dc.identifier.issn1468-6244
dc.identifier.pmid18996907
dc.identifier.doi10.1136/jmg.2008.062232
dc.identifier.urihttp://hdl.handle.net/10541/69556
dc.description.abstractBACKGROUND: Increasingly women at high risk of breast cancer are opting for risk reducing surgery. The aim of this study was to assess the effectiveness of this approach in women at high risk in both carriers and non-carriers of BRCA1/2. METHODS: Data from 10 European centres that offer a genetic counselling and screening service to women at risk were obtained prospectively from 1995. Breast cancer risks were estimated from life tables and a control group of women at risk who did not undergo surgery. RESULTS: The combined centres have data on 550 women who have undergone risk reducing mastectomy with greater than 3334 women years of follow-up. Operations were carried out on women with lifetime risks of 25-80%, with an average expected incidence rate of 1% per year. No breast cancers have occurred in this cohort in the "at risk" unaffected breast, whereas >34 would have been expected. A high rate (2-3.6%) of occult disease was identified in the at risk breast at the time of surgery. INTERPRETATION: We conclude that risk reducing surgery is highly effective.
dc.language.isoenen
dc.subjectBreast Canceren
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshBRCA1 Protein
dc.subject.meshBRCA2 Protein
dc.subject.meshBreast Neoplasms
dc.subject.meshEurope
dc.subject.meshFemale
dc.subject.meshFollow-Up Studies
dc.subject.meshGenetic Counseling
dc.subject.meshGenetic Screening
dc.subject.meshHumans
dc.subject.meshIncidence
dc.subject.meshMastectomy
dc.subject.meshMiddle Aged
dc.subject.meshOvariectomy
dc.subject.meshRisk Factors
dc.subject.meshYoung Adult
dc.titleRisk reducing mastectomy: outcomes in 10 European centres.en
dc.typeArticleen
dc.contributor.departmentCentral Manchester and Manchester Children's University Hospitals NHS Trust, St Mary's Hospital, Manchester, M13 0JH, UK. gareth.evans@cmmc.nhs.uken
dc.identifier.journalJournal of Medical Geneticsen
html.description.abstractBACKGROUND: Increasingly women at high risk of breast cancer are opting for risk reducing surgery. The aim of this study was to assess the effectiveness of this approach in women at high risk in both carriers and non-carriers of BRCA1/2. METHODS: Data from 10 European centres that offer a genetic counselling and screening service to women at risk were obtained prospectively from 1995. Breast cancer risks were estimated from life tables and a control group of women at risk who did not undergo surgery. RESULTS: The combined centres have data on 550 women who have undergone risk reducing mastectomy with greater than 3334 women years of follow-up. Operations were carried out on women with lifetime risks of 25-80%, with an average expected incidence rate of 1% per year. No breast cancers have occurred in this cohort in the "at risk" unaffected breast, whereas >34 would have been expected. A high rate (2-3.6%) of occult disease was identified in the at risk breast at the time of surgery. INTERPRETATION: We conclude that risk reducing surgery is highly effective.


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