• Vaginal leiomyosarcoma.

      Umeadi, Uchenna P; Ahmed, Ahmed S; Slade, Richard J; Menasce, Lia P; Department of Surgery, Christie Hospital NHS Foundation Trust, Manchester, UK. uchenna.umeadi@christie.nhs.uk (2008-07)
    • The value of FDG positron emission tomography/computerised tomography (PET/CT) in pre-operative staging of colorectal cancer: a systematic review and economic evaluation.

      Brush, J; Boyd, K; Chappell, F; Crawford, F; Dozier, M; Fenwick, E; Glanville, J; McIntosh, H; Renehan, Andrew G; Weller, D; et al. (2011-09)
      In the UK, colorectal cancer (CRC) is the third most common malignancy (behind lung and breast cancer) with 37,514 cases registered in 2006: around two-thirds (23,384) in the colon and one-third (14,130) in the rectum. Treatment of cancers of the colon can vary considerably, but surgical resection is the mainstay of treatment for curative intent. Following surgical resection, there is a comprehensive assessment of the tumour, it's invasion characteristics and spread (tumour staging). A number of imaging modalities are used in the pre-operative staging of CRCs including; computerised tomography (CT), magnetic resonance imaging, ultrasound imaging and positron emission tomography (PET). This report examines the role of CT in combination with PET scanning (PET/CT 'hybrid' scan). The research objectives are: to evaluate the diagnostic accuracy and therapeutic impact of fluorine-18-deoxyglucose (FDG) PET/CT for the pre-operative staging of primary, recurrent and metastatic cancer using systematic review methods; undertake probabilistic decision-analytic modelling (using Monte Carlo simulation); and conduct a value of information analysis to help inform whether or not there is potential worth in undertaking further research.
    • What does failure after surgery or radiation mean?

      Clarke, Noel W; Christie and Salford Royal Hospitals, Manchester, UK (2008)
    • What Three Wise Men have to say about diagnosis.

      Mani, Navin; Slevin, Nicholas J; Hudson, Andrew M; Department of Head and Neck Surgical Oncology, Christie Hospital, Manchester M20 4BX, UK. (2011)
    • Which venous system to choose for anastomosis in head and neck reconstructions?

      Ross, Gary L; Ang, Erik S W; Golger, Alex; Lannon, Declan; Addison, Patrick; Snell, Laura; Novak, Christine B; Lipa, Joan E; Gullane, Patrick J; Neligan, Peter C; et al. (2008-10)
      It has been postulated that venous thrombosis in free flap surgery necessitates the use of 2 venous anastomoses into different venous systems.We retrospectively analyzed a single surgeon's 10-year experience (August 1993 to August 2003) in primary free flap reconstruction for malignant tumors of the head and neck. Of 492 primary reconstructions that did not need a vein graft, vein loop, or cephalic turnover procedure, 251 used the internal jugular venous system as venous outflow, 140 used the subclavian system as outflow, and 101 used both.Two hundred thirty-eight of 251 (95%) of flaps utilizing the internal jugular venous system for outflow were successful compared with 129 of 140 (92%) of flaps utilizing the subclavian system. Where both venous systems were used the success rate was 101 of 101 (100%) (P < 0.05).Where possible, a second venous anastomosis should be performed utilizing both venous drainage systems.