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    Acromegaly, growth hormone and cancer risk.

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    Authors
    Renehan, Andrew G
    Brennan, Bernadette M
    Affiliation
    School of Cancer and Imaging Sciences, University of Manchester, Manchester, UK. arenehan@picr.man.ac.uk
    Issue Date
    2008-08
    
    Metadata
    Show full item record
    Abstract
    Acromegaly is an endocrine disorder characterized by sustained hypersecretion of growth hormone (GH) with concomitant elevation of insulin-like growth factor I (IGF-I) associated with premature mortality from cardiopulmonary diseases and certain malignancies. In particular, there is a two-fold increased risk of developing colorectal cancer. Possible mechanisms underlying this association include elevated levels of circulating GH and IGF-I, but several other plausible processes may be relevant. In a parallel literature, there has been debate whether GH replacement therapy is associated with increased cancer risk in three scenarios: (1) tumour recurrence in children with previously treated cancer; (2) second neoplasms (SNs) in survivors of childhood cancer treated with GH; and (3) de-novo cancer in non-cancer patients treated with GH. The general evidence suggests no increased risk in scenario 1. Through a maze of complex study designs, there is inconclusive evidence of a very modest increase in cancer risk in treated GH-deficiency patients in scenarios 2 and 3, but it is likely that the cumulative risk equates to that of the general population. This emphasizes the need for patient selection balanced against the known morbidity of untreated GH deficiency.
    Citation
    Acromegaly, growth hormone and cancer risk. 2008, 22 (4):639-57 Best Pract. Res. Clin. Endocrinol. Metab.
    Journal
    Best Practice & Research. Clinical Endocrinology & Metabolism
    URI
    http://hdl.handle.net/10541/67991
    DOI
    10.1016/j.beem.2008.08.011
    PubMed ID
    18971124
    Type
    Article
    Language
    en
    ISSN
    1532-1908
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.beem.2008.08.011
    Scopus Count
    Collections
    All Christie Publications
    School of Cancer and Imaging Sciences
    Surgery

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