AffiliationSchool of Cancer and Imaging Sciences, University of Manchester, Manchester, UK. firstname.lastname@example.org
MetadataShow full item record
AbstractAcromegaly is an endocrine disorder characterized by sustained hypersecretion of growth hormone (GH) with concomitant elevation of insulin-like growth factor I (IGF-I) associated with premature mortality from cardiopulmonary diseases and certain malignancies. In particular, there is a two-fold increased risk of developing colorectal cancer. Possible mechanisms underlying this association include elevated levels of circulating GH and IGF-I, but several other plausible processes may be relevant. In a parallel literature, there has been debate whether GH replacement therapy is associated with increased cancer risk in three scenarios: (1) tumour recurrence in children with previously treated cancer; (2) second neoplasms (SNs) in survivors of childhood cancer treated with GH; and (3) de-novo cancer in non-cancer patients treated with GH. The general evidence suggests no increased risk in scenario 1. Through a maze of complex study designs, there is inconclusive evidence of a very modest increase in cancer risk in treated GH-deficiency patients in scenarios 2 and 3, but it is likely that the cumulative risk equates to that of the general population. This emphasizes the need for patient selection balanced against the known morbidity of untreated GH deficiency.
CitationAcromegaly, growth hormone and cancer risk. 2008, 22 (4):639-57 Best Pract. Res. Clin. Endocrinol. Metab.
JournalBest Practice & Research. Clinical Endocrinology & Metabolism
- Does growth hormone cause cancer?
- Authors: Jenkins PJ, Mukherjee A, Shalet SM
- Issue date: 2006 Feb
- The effects of long-term growth hormone and insulin-like growth factor-1 exposure on the development of cardiovascular, cerebrovascular and metabolic co-morbidities in treated patients with acromegaly.
- Authors: Jayasena CN, Comninos AN, Clarke H, Donaldson M, Meeran K, Dhillo WS
- Issue date: 2011 Aug
- Hormonal diagnosis of GH hypersecretory states.
- Authors: Grottoli S, Gasco V, Ragazzoni F, Ghigo E
- Issue date: 2003
- Acromegaly and colorectal cancer: a comprehensive review of epidemiology, biological mechanisms, and clinical implications.
- Authors: Renehan AG, O'Connell J, O'Halloran D, Shanahan F, Potten CS, O'Dwyer ST, Shalet SM
- Issue date: 2003 Nov-Dec
- Controversies in the risk of neoplasia in GH deficiency.
- Authors: Pekic S, Stojanovic M, Popovic V
- Issue date: 2017 Feb