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    Meta-analysis in medical research: potentials and limitations.

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    Authors
    Zwahlen, Marcel
    Renehan, Andrew G
    Egger, Matthias
    Affiliation
    Department of Social and Preventive Medicine, University of Berne, Berne, Switzerland. zwahlen@ispm.unibe.ch
    Issue Date
    2009-05-12T18:20:45Z
    
    Metadata
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    Abstract
    Meta-analysis, the statistical combination of results from several studies to produce a single estimate of a treatment effect or size of an association, continues to attract controversy. We illustrate and discuss the promises and limitations of meta-analysis. Meta-analysis of clinical trials can prevent delays in the introduction of effective treatments or lead to the timely identification of adverse effects. However, meta-analyses are liable to numerous biases, both at the level of the individual study and the selection of studies for inclusion in meta-analysis. The biases and confounding factors that threaten the validity of individual studies will also affect meta-analyses of observational studies. We argue that meta-analyses should only be performed within the framework of systematic reviews that have been prepared using methods that minimize bias and address the combinability of studies.
    Citation
    Meta-analysis in medical research: potentials and limitations., 26 (3):320-9 Urol. Oncol.
    Journal
    Urologic Oncology
    URI
    http://hdl.handle.net/10541/67990
    DOI
    10.1016/j.urolonc.2006.12.001
    PubMed ID
    18452828
    Type
    Article
    Language
    en
    ISSN
    1078-1439
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.urolonc.2006.12.001
    Scopus Count
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    All Christie Publications
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