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dc.contributor.authorDe Casso, Carmen
dc.contributor.authorSlevin, Nicholas J
dc.contributor.authorHomer, Jarrod J
dc.date.accessioned2009-05-12T18:08:00Z
dc.date.available2009-05-12T18:08:00Z
dc.date.issued2008-12
dc.identifier.citationThe impact of radiotherapy on swallowing and speech in patients who undergo total laryngectomy. 2008, 139 (6):792- 797 Otolaryngol Head Neck Surgen
dc.identifier.issn0194-5998
dc.identifier.pmid19041505
dc.identifier.doi10.1016/j.otohns.2008.08.023
dc.identifier.urihttp://hdl.handle.net/10541/67986
dc.description.abstractOBJECTIVES: Quality of life studies have shown no detrimental effect with radiotherapy (RT) in patients who have a total laryngectomy. We wished to determine the effect of RT (initial or postoperative) specifically on the swallowing and voice function in patients treated by total laryngectomy (TL) for carcinoma of the larynx. DESIGN: Multicenter chart review. SETTING: Multicenter study in the Greater Manchester and Lancashire area. PARTICIPANTS: A total of 121 postlaryngectomy patients all of whom had completed definitive treatment at least 6 months before this study. Twenty-six patients had total laryngectomy as a single modality treatment and 95 had total laryngectomy and radiotherapy. MAIN OUTCOME MEASURES: Swallowing (solid food, soft diet or fluid/PEG) and voice development. RESULTS: Swallowing was better in the group who had no radiotherapy (P = 0.0037). There was no difference in voice function between the two groups. We also demonstrated that females had a worse swallowing outcome (P = 0.0101), as did advanced nodal stage (P = 0.001). CONCLUSIONS: RT adversely affects the swallowing results but not the speech results after TL when given either as initial treatment or postoperatively. This should be kept in mind in the decision-making process in the treatment of patients with carcinoma of the larynx.
dc.language.isoenen
dc.subjectLaryngeal Canceren
dc.subject.meshAge Factors
dc.subject.meshAged
dc.subject.meshCarcinoma, Squamous Cell
dc.subject.meshChi-Square Distribution
dc.subject.meshCombined Modality Therapy
dc.subject.meshDeglutition Disorders
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshLaryngeal Neoplasms
dc.subject.meshLaryngectomy
dc.subject.meshLogistic Models
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshQuality of Life
dc.subject.meshRadiotherapy Dosage
dc.subject.meshSex Factors
dc.subject.meshTreatment Outcome
dc.subject.meshVoice Disorders
dc.titleThe impact of radiotherapy on swallowing and speech in patients who undergo total laryngectomy.en
dc.typeArticleen
dc.contributor.departmentUniversity Department of Otolaryngology-Head and Neck Surgery, Manchester Royal Infirmary, Manchester, UK. cdecasso@doctors.org.uken
dc.identifier.journalOtolaryngology--Head and Neck Surgeryen
html.description.abstractOBJECTIVES: Quality of life studies have shown no detrimental effect with radiotherapy (RT) in patients who have a total laryngectomy. We wished to determine the effect of RT (initial or postoperative) specifically on the swallowing and voice function in patients treated by total laryngectomy (TL) for carcinoma of the larynx. DESIGN: Multicenter chart review. SETTING: Multicenter study in the Greater Manchester and Lancashire area. PARTICIPANTS: A total of 121 postlaryngectomy patients all of whom had completed definitive treatment at least 6 months before this study. Twenty-six patients had total laryngectomy as a single modality treatment and 95 had total laryngectomy and radiotherapy. MAIN OUTCOME MEASURES: Swallowing (solid food, soft diet or fluid/PEG) and voice development. RESULTS: Swallowing was better in the group who had no radiotherapy (P = 0.0037). There was no difference in voice function between the two groups. We also demonstrated that females had a worse swallowing outcome (P = 0.0101), as did advanced nodal stage (P = 0.001). CONCLUSIONS: RT adversely affects the swallowing results but not the speech results after TL when given either as initial treatment or postoperatively. This should be kept in mind in the decision-making process in the treatment of patients with carcinoma of the larynx.


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