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    Obesity and cancer: pathophysiological and biological mechanisms.

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    Authors
    Renehan, Andrew G
    Roberts, Darren L
    Dive, Caroline
    Affiliation
    Department of Surgery, School of Cancer and Imaging Sciences, University of Manchester, Christie Hospital NHS Foundation Trust, Wilmslow Road, Manchester, UK. arenehan@picr.man.ac.uk
    Issue Date
    2008-02
    
    Metadata
    Show full item record
    Abstract
    Excess body weight (overweight and obesity) is characterized by chronic hyperinsulinaemia and insulin resistance, and is implicated both in cancer risk and cancer mortality. The list of cancers at increased risk of development in an "obesogenic" environment include common adult cancers such as endometrium, post-menopausal breast, colon and kidney, but also less common malignancies such as leukaemia, multiple myeloma, and non-Hodgkin's lymphoma. The pathophysiological and biological mechanisms underpinning these associations are only starting to be understood. Insulin resistance is at the heart of many, but there are several other candidate systems including insulin-like growth factors, sex steroids, adipokines, obesity-related inflammatory markers, the nuclear factor kappa beta (NF-kappa B) system and oxidative stresses. With such as diversity of obesity-related cancers, it is unlikely that there is a "one system fits all" mechanism. While public health strategies to curb the spread of the obesity epidemic appear ineffective, there is a need to better understand the processes linking obesity and cancer as a pre-requisite to the development of new approaches to the prevention and treatment of obesity-related cancers.
    Citation
    Obesity and cancer: pathophysiological and biological mechanisms. 2008, 114 (1):71-83 Arch. Physiol. Biochem.
    Journal
    Archives of Physiology and Biochemistry
    URI
    http://hdl.handle.net/10541/67939
    DOI
    10.1080/13813450801954303
    PubMed ID
    18465361
    Type
    Article
    Language
    en
    ISSN
    1381-3455
    ae974a485f413a2113503eed53cd6c53
    10.1080/13813450801954303
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research
    Clinical and Experimental Pharmacology Group
    School of Cancer and Imaging Sciences

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