A phase II trial of lomeguatrib and temozolomide in metastatic colorectal cancer.
Authors
Khan, O ARanson, Malcolm R
Michael, M
Olver, I
Levitt, N C
Mortimer, Peter
Watson, Amanda J
Margison, Geoffrey P
Midgley, R
Middleton, Mark R
Affiliation
CR UK Medical Oncology Unit, Churchill Hospital, Old Road, Oxford OX3 7LJ, UK.Issue Date
2008-05-20
Metadata
Show full item recordAbstract
To evaluate the tumour response to lomeguatrib and temozolomide (TMZ) administered for 5 consecutive days every 4 weeks in patients with metastatic colorectal carcinoma. Patients with stage IV metastatic colorectal carcinoma received lomeguatrib (40 mg) and TMZ (50-200 mg m(-2)) orally for 5 consecutive days every 4 weeks. Response was determined every two cycles. Pharmacokinetics of lomeguatrib and TMZ as well as their pharmacodynamic effects in peripheral blood mononuclear cells (PBMC) were determined. Nineteen patients received 49 cycles of treatments. Despite consistent depletion of O(6)-methylguanine-DNA methyltransferase in PBMC, none of the patients responded to treatment. Three patients had stable disease, one for the duration of the study, and no fall in carcinoembryonic antigen was observed in any patient. Median time to progression was 50 days. The commonest adverse effects were gastrointestinal and haematological and these were comparable to those of TMZ when given alone. This combination of lomeguatrib and TMZ is not efficacious in metastatic colorectal cancer. If further studies are to be performed, emerging data suggest that higher daily doses of lomeguatrib and a dosing period beyond that of TMZ should be evaluated.Citation
A phase II trial of lomeguatrib and temozolomide in metastatic colorectal cancer. 2008, 98 (10):1614-8 Br. J. CancerJournal
British Journal of CancerDOI
10.1038/sj.bjc.6604366PubMed ID
18475294Type
ArticleLanguage
enISSN
1532-1827ae974a485f413a2113503eed53cd6c53
10.1038/sj.bjc.6604366