GH replacement reduces increased lipid peroxidation in GH-deficient adults.
Lewandowski, Krzysztof C
Shalet, Stephen M
AffiliationDepartment of Oncological Endocrinology, Medical University, Lodz, Poland.
MetadataShow full item record
AbstractBACKGROUND: GH replacement improves numerous metabolic abnormalities in GH-deficient patients; increased lipid peroxidation (LPO) has been observed in GH-deficient patients; however, it is unknown if LPO is influenced by GH replacement. AIM AND METHODS: To evaluate the extent to which GH replacement might reverse the increased LPO in GH-deficient adults and to analyse if this phenomenon might be involved in the improvement of metabolic disturbances due to GH treatment. Serum concentrations of malondialdehyde + 4-hydroxyalkenals (MDA + 4-HDA), as an index of LPO, were measured at baseline, and after 12 and 24 months of GH replacement in 40 adult patients with severe GH deficiency (both in adult- and childhood-onset) and in 40 healthy volunteers, matched for sex, age and body mass index (BMI). Correlations were evaluated between LPO and lipids, IGF-I, metalloproteinase-2 and -9 (MMP-2, -9), vascular endothelial growth factor (VEGF), BMI and GH dose. RESULTS: LPO values in GH-deficient patients were several-fold higher than in controls [55.36 +/- 2.27 vs. 4.19 +/- 0.42 nmol/mg protein (mean +/- SEM), P < 0.0001] and decreased significantly over time with GH replacement to 38.61 +/- 2.15 nmol/mg protein (i.e. by approximately 30%), though still remaining markedly elevated compared with controls (P < 0.0001). The proatherogenic lipid profile parameters correlated positively with LPO in the childhood-onset subgroup before GH replacement. GH replacement restored the positive correlation between LPO and age in male patients (r = 0.57, P = 0.013; r = 0.8, P < 0.001, at 12 and 24 months of GH replacement, respectively). CONCLUSIONS: GH replacement partially reverses the grossly abnormal LPO in GH-deficient adults. It is highly probable, therefore, that oxidative mechanisms are involved in the overall improvement of metabolic changes due to GH replacement.
CitationGH replacement reduces increased lipid peroxidation in GH-deficient adults. 2008, 68 (6):957-64 Clin. Endocrinol.
- Increased lipid peroxidation in growth hormone-deficient adult patients.
- Authors: Kokoszko A, Karbownik M, Lewiński A
- Issue date: 2006 Feb-Apr
- Improvement in insulin sensitivity without concomitant changes in body composition and cardiovascular risk markers following fixed administration of a very low growth hormone (GH) dose in adults with severe GH deficiency.
- Authors: Yuen KC, Frystyk J, White DK, Twickler TB, Koppeschaar HP, Harris PE, Fryklund L, Murgatroyd PR, Dunger DB
- Issue date: 2005 Oct
- Low-dose GH replacement improves the adverse lipid profile associated with the adult GH deficiency syndrome.
- Authors: Murray RD, Wieringa GE, Lissett CA, Darzy KH, Smethurst LE, Shalet SM
- Issue date: 2002 Apr
- Safety and efficacy of growth hormone (GH) during extended treatment of adult Japanese patients with GH deficiency (GHD).
- Authors: Chihara K, Kato Y, Kohno H, Takano K, Tanaka T, Teramoto A, Shimatsu A
- Issue date: 2008 Aug
- GH sensitivity of GH-deficient adults is dependent on gender but not timing of onset.
- Authors: Columb B, Smethurst LE, Mukherjee A, Jostel A, Shalet SM, Murray RD
- Issue date: 2009 Feb