GH replacement reduces increased lipid peroxidation in GH-deficient adults.
Authors
Karbownik-Lewinska, MalgorzataKokoszko, Agnieszka
Lewandowski, Krzysztof C
Shalet, Stephen M
Lewinski, Andrzej
Affiliation
Department of Oncological Endocrinology, Medical University, Lodz, Poland.Issue Date
2008-06
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BACKGROUND: GH replacement improves numerous metabolic abnormalities in GH-deficient patients; increased lipid peroxidation (LPO) has been observed in GH-deficient patients; however, it is unknown if LPO is influenced by GH replacement. AIM AND METHODS: To evaluate the extent to which GH replacement might reverse the increased LPO in GH-deficient adults and to analyse if this phenomenon might be involved in the improvement of metabolic disturbances due to GH treatment. Serum concentrations of malondialdehyde + 4-hydroxyalkenals (MDA + 4-HDA), as an index of LPO, were measured at baseline, and after 12 and 24 months of GH replacement in 40 adult patients with severe GH deficiency (both in adult- and childhood-onset) and in 40 healthy volunteers, matched for sex, age and body mass index (BMI). Correlations were evaluated between LPO and lipids, IGF-I, metalloproteinase-2 and -9 (MMP-2, -9), vascular endothelial growth factor (VEGF), BMI and GH dose. RESULTS: LPO values in GH-deficient patients were several-fold higher than in controls [55.36 +/- 2.27 vs. 4.19 +/- 0.42 nmol/mg protein (mean +/- SEM), P < 0.0001] and decreased significantly over time with GH replacement to 38.61 +/- 2.15 nmol/mg protein (i.e. by approximately 30%), though still remaining markedly elevated compared with controls (P < 0.0001). The proatherogenic lipid profile parameters correlated positively with LPO in the childhood-onset subgroup before GH replacement. GH replacement restored the positive correlation between LPO and age in male patients (r = 0.57, P = 0.013; r = 0.8, P < 0.001, at 12 and 24 months of GH replacement, respectively). CONCLUSIONS: GH replacement partially reverses the grossly abnormal LPO in GH-deficient adults. It is highly probable, therefore, that oxidative mechanisms are involved in the overall improvement of metabolic changes due to GH replacement.Citation
GH replacement reduces increased lipid peroxidation in GH-deficient adults. 2008, 68 (6):957-64 Clin. Endocrinol.Journal
Clinical EndocrinologyDOI
10.1111/j.1365-2265.2007.03142.xPubMed ID
18031310Type
ArticleLanguage
enISSN
1365-2265ae974a485f413a2113503eed53cd6c53
10.1111/j.1365-2265.2007.03142.x
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