AffiliationDepartment of Endocrinology, Christie Hospital, Manchester, UK. firstname.lastname@example.org
MetadataShow full item record
AbstractPURPOSE OF REVIEW: To consider the current status and types of drug therapy aimed at restoring eucortisolaemia in patients with Cushing's syndrome. RECENT FINDINGS: Advances such as laparoscopic adrenalectomy modify the exact placing of drug therapy among the wide variety of therapies available to treat patients with Cushing's syndrome because of different causes; nonetheless, it is now clear that hypercortisolism, per se, if present for any length of time, modifies the future prognosis of the patient, even after cure of the Cushing's syndrome. Thus, early diagnosis and restoration of eucortisolsm are critical. There are three main types of drug therapy: steroidogenesis inhibitors, glucocorticoid antagonists and neuromodulatory compounds. Currently, steroidogenesis inhibitors such as metyrapone and ketaconazole are most commonly the first choice if drug therapy is to be used, but at least for the most common form of Cushing's syndrome, Cushing's disease, the neuromodulatory compounds such as cabergoline show potential. SUMMARY: Pharmacological therapy for Cushing's syndrome remains critically important for normalizing cortisol levels while awaiting the impact of more definitive treatment.
CitationPharmacological treatment of hypercortisolism. 2008, 15 (3):234-8 Curr Opin Endocrinol Diabetes Obes
JournalCurrent Opinion in Endocrinology, Diabetes, and Obesity
- Medical treatment of Cushing's syndrome: adrenal-blocking drugs and ketaconazole.
- Authors: Feelders RA, Hofland LJ, de Herder WW
- Issue date: 2010
- Drugs in the medical treatment of Cushing's syndrome.
- Authors: Schteingart DE
- Issue date: 2009 Dec
- Cushing's syndrome of nonpituitary causes.
- Authors: Carroll TB, Findling JW
- Issue date: 2009 Aug
- Management of diabetes mellitus in Cushing's syndrome.
- Authors: Munir A, Newell-Price J
- Issue date: 2010
- Pharmacological therapy of Cushing's syndrome: drugs and indications.
- Authors: Díez JJ, Iglesias P
- Issue date: 2007 May