Effects of antiepileptic drug therapy on vitamin D status and biochemical markers of bone turnover in children with epilepsy.
Brabant, Georg E
AffiliationNutrition Physiology and Human Nutrition Unit, Institute of Food Science, Leibniz University of Hannover, Wunstorfer Str. 14, 30453, Hannover, Germany. firstname.lastname@example.org
MetadataShow full item record
AbstractReports of decreased serum 25-hydroxyvitamin D (25-OHD) and altered bone metabolism associated with antiepileptic drug (AED) treatment are inconsistent and predominantly restricted to adults. In this cross-sectional observational study, the aim was to evaluate the influence of AED treatment on vitamin D status and markers of bone turnover in children with epilepsy. In 38 children taking AEDs and 44 healthy control subjects, blood samples were collected to determine the levels of serum 25-OHD, intact parathyroid hormone (iPTH), calcium (Ca), phosphate (P), bone alkaline phosphatase (BAP), osteocalcin (OC) and C terminal telopeptide of type I collagen (ICTP). More than 75% of the patients were vitamin D deficient (serum 25-OHD<20 ng/mL) and 21% of the patients had an insufficient vitamin D status (serum 25-OHD=20-30 ng/mL). In the patients, the serum levels of OC (p = 0.002) and BAP (p < 0.001) were significantly increased, but ICTP (p = 0.002) concentrations were significantly decreased compared with the control group. When patients where divided into two groups according to their medication (mono- or polytherapy), significantly lower 25-OHD (p = 0.038) and ICTP (p = 0.005) levels and elevated BAP (p = 0.023) concentrations were found in patients under polytherapy. An association between 25-OHD and the measured bone markers could not be determined. Our results indicate that the prevalence of vitamin D deficiency in epilepsy patients under AED treatment is high, especially under polytherapy, and alteration markers of bone formation and resorption suggests an accelerated skeletal turnover. The routine monitoring of serum 25-OHD and vitamin D supplementation on an individual basis should be considered.
CitationEffects of antiepileptic drug therapy on vitamin D status and biochemical markers of bone turnover in children with epilepsy. 2008, 167 (12):1369-77 Eur. J. Pediatr.
JournalEuropean Journal of Pediatrics
- Vitamin D levels and bone turnover in epilepsy patients taking carbamazepine or oxcarbazepine.
- Authors: Mintzer S, Boppana P, Toguri J, DeSantis A
- Issue date: 2006 Mar
- Vitamin D supplementation has minor effects on parathyroid hormone and bone turnover markers in vitamin D-deficient bedridden older patients.
- Authors: Björkman M, Sorva A, Risteli J, Tilvis R
- Issue date: 2008 Jan
- Vitamin D status in children with intractable epilepsy, and impact of the ketogenic diet.
- Authors: Bergqvist AG, Schall JI, Stallings VA
- Issue date: 2007 Jan
- Vitamin D status and markers of bone turnover in Caucasian and South Asian postmenopausal women living in the UK.
- Authors: Lowe NM, Mitra SR, Foster PC, Bhojani I, McCann JF
- Issue date: 2010 Jun
- Calcium metabolism serum markers in adult patients with epilepsy and the effect of vitamin D supplementation on seizure control.
- Authors: Tombini M, Palermo A, Assenza G, Pellegrino G, Benvenga A, Campana C, Naciu AM, Assenza F, Lazzaro VD
- Issue date: 2018 May