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    Effects of antiepileptic drug therapy on vitamin D status and biochemical markers of bone turnover in children with epilepsy.

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    Authors
    Nettekoven, Sina
    Ströhle, Alexander
    Trunz, Birgit
    Wolters, Maike
    Hoffmann, Susanne
    Horn, R
    Steinert, Martin
    Brabant, Georg E
    Lichtinghagen, Ralf
    Welkoborsky, Hans-Jürgen
    Tuxhorn, Ingrid
    Hahn, Andreas
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    Affiliation
    Nutrition Physiology and Human Nutrition Unit, Institute of Food Science, Leibniz University of Hannover, Wunstorfer Str. 14, 30453, Hannover, Germany. sina.nettekoven@lw.uni-hannover.de
    Issue Date
    2008-12
    
    Metadata
    Show full item record
    Abstract
    Reports of decreased serum 25-hydroxyvitamin D (25-OHD) and altered bone metabolism associated with antiepileptic drug (AED) treatment are inconsistent and predominantly restricted to adults. In this cross-sectional observational study, the aim was to evaluate the influence of AED treatment on vitamin D status and markers of bone turnover in children with epilepsy. In 38 children taking AEDs and 44 healthy control subjects, blood samples were collected to determine the levels of serum 25-OHD, intact parathyroid hormone (iPTH), calcium (Ca), phosphate (P), bone alkaline phosphatase (BAP), osteocalcin (OC) and C terminal telopeptide of type I collagen (ICTP). More than 75% of the patients were vitamin D deficient (serum 25-OHD<20 ng/mL) and 21% of the patients had an insufficient vitamin D status (serum 25-OHD=20-30 ng/mL). In the patients, the serum levels of OC (p = 0.002) and BAP (p < 0.001) were significantly increased, but ICTP (p = 0.002) concentrations were significantly decreased compared with the control group. When patients where divided into two groups according to their medication (mono- or polytherapy), significantly lower 25-OHD (p = 0.038) and ICTP (p = 0.005) levels and elevated BAP (p = 0.023) concentrations were found in patients under polytherapy. An association between 25-OHD and the measured bone markers could not be determined. Our results indicate that the prevalence of vitamin D deficiency in epilepsy patients under AED treatment is high, especially under polytherapy, and alteration markers of bone formation and resorption suggests an accelerated skeletal turnover. The routine monitoring of serum 25-OHD and vitamin D supplementation on an individual basis should be considered.
    Citation
    Effects of antiepileptic drug therapy on vitamin D status and biochemical markers of bone turnover in children with epilepsy. 2008, 167 (12):1369-77 Eur. J. Pediatr.
    Journal
    European Journal of Pediatrics
    URI
    http://hdl.handle.net/10541/65742
    DOI
    10.1007/s00431-008-0672-7
    PubMed ID
    18270736
    Type
    Article
    Language
    en
    ISSN
    1432-1076
    ae974a485f413a2113503eed53cd6c53
    10.1007/s00431-008-0672-7
    Scopus Count
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    All Christie Publications
    Endocrinology

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