Cancer in pregnancy (CARING) - a retrospective study of cancer diagnosed during pregnancy in the United Kingdom
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Authors
Baxter, M. A.Denholm, M.
Kingdon, S. J.
Kathirgamakarthigeyan, S.
Parikh, S.
Shakir, R.
Johnson, R.
Martin, H.
Walton, M.
Yao, W.
Swan, A.
Samuelson, C.
Ren, X.
Cooper, A.
Gray, H. L.
Clifton, S.
Ball, J.
Gullick, G.
Anderson, M.
Dodd, L.
Hayhurst, H.
Salama, M.
Shotton, Rohan
Britton, Fiona
Christodoulou, T.
Abdul-Hamid, A.
Eichholz, A.
Evans, R. M.
Wallroth, P.
Gibson, F.
Poole, K.
Rowe, M.
Harris, J.
Natl Oncology, T.
Affiliation
Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, UKIssue Date
2024
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BackgroundThe incidence of cancer diagnosed during pregnancy is increasing. Data relating to investigation and management, as well as maternal and foetal outcomes is lacking in a United Kingdom (UK) population.MethodsIn this retrospective study we report data from 119 patients diagnosed with cancer during pregnancy from 14 cancer centres in the UK across a five-year period (2016-2020).ResultsMedian age at diagnosis was 33 years, with breast, skin and haematological the most common primary sites. The majority of cases were new diagnoses (109 patients, 91.6%). Most patients were treated with radical intent (96 patients, 80.7%), however, gastrointestinal cancers were associated with a high rate of palliative intent treatment (63.6%). Intervention was commenced during pregnancy in 68 (57.1%) patients; 44 (37%) had surgery and 31 (26.1%) received chemotherapy. Live births occurred in 98 (81.7%) of the cases, with 54 (55.1%) of these delivered by caesarean section. Maternal mortality during the study period was 20.2%.ConclusionsThis is the first pan-tumour report of diagnosis, management and outcomes of cancer diagnosed during pregnancy in the UK. Our findings demonstrate proof of concept that data collection is feasible and highlight the need for further research in this cohort of patients.Citation
Baxter MA, Denholm M, Kingdon SJ, Kathirgamakarthigeyan S, Parikh S, Shakir R, et al. CAnceR IN PreGnancy (CARING) - a retrospective study of cancer diagnosed during pregnancy in the United Kingdom. British journal of cancer. 2024 MAY 3;130(8):1261-8. PubMed PMID: WOS:001168929300001. English.Journal
British Journal of CancerDOI
10.1038/s41416-024-02605-xPubMed ID
38383704Additional Links
https://dx.doi.org/10.1038/s41416-024-02605-xType
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.1038/s41416-024-02605-x
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