Show simple item record

dc.contributor.authorGheybi, K.en
dc.contributor.authorMmekwa, N.en
dc.contributor.authorLebelo, M. T.en
dc.contributor.authorPatrick, S. M.en
dc.contributor.authorCampbell, R.en
dc.contributor.authorNenzhelele, M.en
dc.contributor.authorSoh, P. X. Y.en
dc.contributor.authorObida, M.en
dc.contributor.authorLoda, M.en
dc.contributor.authorShirindi, J.en
dc.contributor.authorButler, E. N.en
dc.contributor.authorMutambirwa, S. B. A.en
dc.contributor.authorBornman, M. S. R.en
dc.contributor.authorHayes, Vanessa Men
dc.date.accessioned2024-01-29T13:19:51Z
dc.date.available2024-01-29T13:19:51Z
dc.date.issued2023en
dc.identifier.citationGheybi K, Mmekwa N, Lebelo MT, Patrick SM, Campbell R, Nenzhelele M, et al. Linking African ancestral substructure to prostate cancer health disparities. Scientific reports. 2023 Nov 27;13(1):20909. PubMed PMID: 38017150. Pubmed Central PMCID: PMC10684577. Epub 2023/11/29. eng.en
dc.identifier.pmid38017150en
dc.identifier.doi10.1038/s41598-023-47993-xen
dc.identifier.urihttp://hdl.handle.net/10541/626862
dc.description.abstractProstate cancer (PCa) is a significant health burden in Sub-Saharan Africa, with mortality rates loosely linked to African ancestry. Yet studies aimed at identifying contributing risk factors are lacking within the continent and as such exclude for significant ancestral diversity. Here, we investigate a series of epidemiological demographic and lifestyle risk factors for 1387 men recruited as part of the multi-ethnic Southern African Prostate Cancer Study (SAPCS). We found poverty to be a decisive factor for disease grade and age at diagnosis, with other notably significant PCa associated risk factors including sexually transmitted diseases, erectile dysfunction, gynaecomastia, and vertex or complete pattern balding. Aligned with African American data, Black ethnicity showed significant risk for PCa diagnosis (OR = 1.44, 95% CI 1.05-2.00), and aggressive disease presentation (ISUP ≥ 4: OR = 2.25, 95% CI   1.49-3.40). New to this study, we demonstrate African ancestral population substructure associated PCa disparity, observing increased risk for advanced disease for the southern African Tsonga people (ISUP ≥ 4: OR = 3.43, 95% CI   1.62-7.27). Conversely, South African Coloured were less likely to be diagnosed with aggressive disease overall (ISUP ≥ 3: OR = 0.38, 95% 0.17-0.85). Understanding the basis for PCa health disparities calls for African inclusion, however, lack of available data has limited the power to begin discussions. Here, focusing on arguably the largest study of its kind for the African continent, we draw attention to the contribution of within African ancestral diversity as a contributing factor to PCa health disparities within the genetically diverse region of southern Africa.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1038/s41598-023-47993-xen
dc.titleLinking African ancestral substructure to prostate cancer health disparitiesen
dc.typeArticleen
dc.contributor.departmentManchester Cancer Research Centre, University of Manchester, Manchester, M20 4GJ, UK.en
dc.identifier.journalScientific Reportsen
dc.description.noteen]
refterms.dateFOA2024-01-30T17:22:18Z


Files in this item

Thumbnail
Name:
Linking African.pdf
Size:
1.673Mb
Format:
PDF
Description:
Found with Open Access Button

This item appears in the following Collection(s)

Show simple item record