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dc.contributor.authorSoh, PXYen
dc.contributor.authorMmekwa, Nen
dc.contributor.authorPetersen, DCen
dc.contributor.authorGheybi, Ken
dc.contributor.authorvan Zyl, Sen
dc.contributor.authorJiang, Jen
dc.contributor.authorPatrick, SMen
dc.contributor.authorCampbell, Ren
dc.contributor.authorJaratlerdseri, Wen
dc.contributor.authorMutambirwa, SBAen
dc.contributor.authorBornman, MSRen
dc.contributor.authorHayes, Vanessa Men
dc.date.accessioned2024-01-29T13:19:50Z
dc.date.available2024-01-29T13:19:50Z
dc.date.issued2023en
dc.identifier.citationSoh PXY, Mmekwa N, Petersen DC, Gheybi K, van Zyl S, Jiang J, et al. Prostate cancer genetic risk and associated aggressive disease in men of African ancestry. Nature communications. 2023 Dec 5;14(1):8037. PubMed PMID: 38052806. Pubmed Central PMCID: PMC10697980. Epub 2023/12/06. eng.en
dc.identifier.pmid38052806en
dc.identifier.doi10.1038/s41467-023-43726-wen
dc.identifier.urihttp://hdl.handle.net/10541/626860
dc.description.abstractAfrican ancestry is a significant risk factor for prostate cancer and advanced disease. Yet, genetic studies have largely been conducted outside the context of Sub-Saharan Africa, identifying 278 common risk variants contributing to a multiethnic polygenic risk score, with rare variants focused on a panel of roughly 20 pathogenic genes. Based on this knowledge, we are unable to determine polygenic risk or differentiate prostate cancer status interrogating whole genome data for 113 Black South African men. To further assess for potentially functional common and rare variant associations, here we interrogate 247,780 exomic variants for 798 Black South African men using a case versus control or aggressive versus non-aggressive study design. Notable genes of interest include HCP5, RFX6 and H3C1 for risk, and MKI67 and KLF5 for aggressive disease. Our study highlights the need for further inclusion across the African diaspora to establish African-relevant risk models aimed at reducing prostate cancer health disparities.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1038/s41467-023-43726-wen
dc.titleProstate cancer genetic risk and associated aggressive disease in men of African ancestryen
dc.typeArticleen
dc.contributor.departmentManchester Cancer Research Centre, University of Manchester, Manchester, M20 4GJ, UKen
dc.identifier.journalNature Communicationsen
dc.description.noteen]
refterms.dateFOA2024-02-01T09:46:35Z


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