POTEE promotes breast cancer cell malignancy by inducing invadopodia formation through the activation of SUMOylated Rac1
Authors
Martínez-López, A.García-Casas, A.
Infante, G.
González-Fernández, M.
Salvador, N.
Lorente, M.
Mendiburu-Eliçabe, M.
Gonzalez-Moreno, S.
Villarejo-Campos, P.
Velasco, G.
Malliri, Angeliki
Castillo-Lluva, S.
Affiliation
Cancer Research UK Manchester Institute, The University of Manchester, UK.Issue Date
2023
Metadata
Show full item recordAbstract
The small GTPase Rac1 (Ras-related C3 botulinum toxin substrate 1) has been implicated in cancer progression and in the poor prognosis of various types of tumors. Rac1 SUMOylation occurs during epithelial-mesenchymal transition (EMT), and it is required for tumor cell migration and invasion. Here we identify POTEE (POTE Ankyrin domain family member E) as a novel Rac1-SUMO1 effector involved in breast cancer malignancy that controls invadopodium formation through the activation of Rac1-SUMO1. POTEE activates Rac1 in the invadopodium by recruiting TRIO-GEF (triple functional domain protein), and it induces tumor cell proliferation and metastasis in vitro and in vivo. We found that the co-localization of POTEE with Rac1 is correlated with more aggressive breast cancer subtypes. Given its role in tumor dissemination, the leading cause of cancer-related deaths, POTEE could represent a potential therapeutic target for these types of cancer.Citation
Martínez-López A, García-Casas A, Infante G, González-Fernández M, Salvador N, Lorente M, et al. POTEE promotes breast cancer cell malignancy by inducing invadopodia formation through the activation of SUMOylated Rac1. Molecular oncology. 2023 Dec 14. PubMed PMID: 38098337. Epub 2023/12/15. eng.Journal
Molecular OncologyDOI
10.1002/1878-0261.13568PubMed ID
38098337Additional Links
https://dx.doi.org/10.1002/1878-0261.13568Type
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.1002/1878-0261.13568
Scopus Count
Collections
Related articles
- POTEE promotes colorectal carcinoma progression via activating the Rac1/Cdc42 pathway.
- Authors: Xu Q, Chen J, Peng M, Duan S, Hu Y, Guo D, Geng J, Zhou J
- Issue date: 2020 May 1
- Two distinct mTORC2-dependent pathways converge on Rac1 to drive breast cancer metastasis.
- Authors: Morrison Joly M, Williams MM, Hicks DJ, Jones B, Sanchez V, Young CD, Sarbassov DD, Muller WJ, Brantley-Sieders D, Cook RS
- Issue date: 2017 Jun 30
- BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study.
- Authors: Makrodouli E, Oikonomou E, Koc M, Andera L, Sasazuki T, Shirasawa S, Pintzas A
- Issue date: 2011 Sep 23
- A Trio-Rac1-Pak1 signalling axis drives invadopodia disassembly.
- Authors: Moshfegh Y, Bravo-Cordero JJ, Miskolci V, Condeelis J, Hodgson L
- Issue date: 2014 Jun
- RAC1-GTP promotes epithelial-mesenchymal transition and invasion of colorectal cancer by activation of STAT3.
- Authors: Zhou K, Rao J, Zhou ZH, Yao XH, Wu F, Yang J, Yang L, Zhang X, Cui YH, Bian XW, Shi Y, Ping YF
- Issue date: 2018 Aug