Overweight-years and cancer risk: a prospective study of the association and comparison of predictive performance with body mass index (atherosclerosis risk in communities study)
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Intl Journal of Cancer - 2023 - ...
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Cancer Research UK, Manchester Cancer Research Centre, Manchester, UK.Issue Date
2023
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Excess body mass index (BMI) is associated with a higher risk of at least 13 cancers, but it is usually measured at a single time point. We tested whether the overweight-years metric, which incorporates exposure time to BMI ≥25 kg/m(2) , is associated with cancer risk and compared this with a single BMI measure. We used adulthood BMI readings in the Atherosclerosis Risk in Communities (ARIC) study to derive the overweight-years metric. We calculated associations between the metric and BMI and the risk of cancers using Cox proportional hazards models. Models that either included the metric or BMI were compared using Harrell's C-statistic. We included 13,463 participants, with 3,876 first primary cancers over a mean of 19 years (SD 7) of cancer follow-up. Hazard ratios for obesity-related cancers per standard deviation overweight-years were 1.15 (95% CI: 1.05-1.25) in men and 1.14 (95% CI: 1.08-1.20) in women. The difference in the C-statistic between models that incorporated BMI, or the overweight-years metric was non-significant in men and women. Overweight-years was associated with the risk of obesity-related cancers but did not outperform a single BMI measure in association performance characteristics.Citation
Hawwash NK, Sperrin M, Martin GP, Joshu CE, Florido R, Platz EA, et al. Overweight-years and cancer risk: A prospective study of the association and comparison of predictive performance with body mass index (Atherosclerosis Risk in Communities Study). Int J Cancer. 2023 Dec 24. PubMed PMID: 38143298. Epub 2023/12/25. eng.Journal
International Journal of CancerDOI
10.1002/ijc.34821PubMed ID
38143298Additional Links
https://dx.doi.org/10.1002/ijc.34821Type
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.1002/ijc.34821
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