Hitting the target: developing high-quality evidence for proton beam therapy through randomised controlled trials
Name:
Hitting the Target_ Developing ...
Size:
276.1Kb
Format:
PDF
Description:
Found with Open Access Button
Authors
Hudson, E. M.Slevin, F.
Biscombe, K.
Brown, S. R.
Haviland, J. S.
Murray, L.
Kirby, A. M.
Thomson, David J
Sebag-Montefiore, D.
Hall, E.
Affiliation
The Christie NHS Foundation Trust, Manchester, UK.Issue Date
2024
Metadata
Show full item recordAbstract
The National Health Service strategy for the delivery of proton beam therapy (PBT) in the UK provides a unique opportunity to deliver high-quality evidence for PBT through randomised controlled trials (RCTs). We present a summary of three UK PBT RCTs in progress, including consideration of their key design characteristics and outcome assessments, to inform and support future PBT trial development. The first three UK multicentre phase III PBT RCTs (TORPEdO, PARABLE and APPROACH), will compare PBT with photon radiotherapy for oropharyngeal squamous cell carcinoma, breast cancer and oligodendroglioma, respectively. All three studies were designed by multidisciplinary teams, which combined expertise from clinicians, clinical trialists and scientists with strong patient advocacy and guidance from national radiotherapy research networks and international collaborators. Consistent across all three studies is a focus on the reduction of long-term radiotherapy-related toxicities and an evaluation of patient-reported outcomes and health-related quality of life, which will address key uncertainties regarding the clinical benefits of PBT. Innovative translational components will provide insights into mechanisms of toxicity and help to frame the key future research questions regarding PBT. The UK radiotherapy research community is developing and delivering an internationally impactful PBT research portfolio. The combination of data from RCTs with prospectively collected data from a national PBT outcomes registry will provide an innovative, high-quality repository for PBT research and the platform to design and deliver future trials of PBT.Citation
Hudson EM, Slevin F, Biscombe K, Brown SR, Haviland JS, Murray L, et al. Hitting the Target: Developing High-quality Evidence for Proton Beam Therapy Through Randomised Controlled Trials. Clinical oncology (Royal College of Radiologists (Great Britain)). 2024 Feb;36(2):70-9. PubMed PMID: 38042671. Epub 2023/12/03. eng.Journal
Clinical Oncology (R Coll Radiol)DOI
10.1016/j.clon.2023.11.027PubMed ID
38042671Additional Links
https://dx.doi.org/10.1016/j.clon.2023.11.027Type
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.1016/j.clon.2023.11.027
Scopus Count
Collections
Related articles
- Systematic review of methodology used in clinical studies evaluating the benefits of proton beam therapy.
- Authors: Ofuya M, McParland L, Murray L, Brown S, Sebag-Montefiore D, Hall E
- Issue date: 2019 Nov
- Establishing Evidence-Based Indications for Proton Therapy: An Overview of Current Clinical Trials.
- Authors: Mishra MV, Aggarwal S, Bentzen SM, Knight N, Mehta MP, Regine WF
- Issue date: 2017 Feb 1
- Hadrontherapy for cancer. An overview of HTA reports and ongoing studies.
- Authors: Jefferson T, Formoso G, Venturelli F, Vicentini M, Chiarolla E, Ballini L
- Issue date: 2019 Dec
- Proton Beam Therapy - the Challenges of Delivering High-quality Evidence of Clinical Benefit.
- Authors: National Cancer Research Institute Clinical and Translational Radiotherapy Research Working Group (CTRad) Proton Beam Clinical Trial Strategy Group
- Issue date: 2018 May
- The future of Cochrane Neonatal.
- Authors: Soll RF, Ovelman C, McGuire W
- Issue date: 2020 Nov