Impact of bariatric surgery on ABC subtilisin/kexin type 9 (PCSK9) gene expression and inflammation in the adipose tissue of obese diabetic rats
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Authors
Heald, A. H.Fachim, H. A.
Bashir, B.
Garside, B.
Adam, Safwaan
Iqbal, Z.
Syed, A. A.
Donn, R.
Le Roux, C. W.
Abdelaal, M.
White, J.
Soran, H.
Affiliation
The Christie Hospital NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK.Issue Date
2023
Metadata
Show full item recordAbstract
Bariatric surgery improves dyslipidaemia and reduces body weight, but it remains unclear how bariatric surgery modulates gene expression in fat cells to influence the proprotein convertase subtilisin/kexin type 9 (PCSK-9) and low-density lipoprotein receptor (LDLR) gene expression. The expression of the PCSK9/LDLR/tumor necrosis factor-alpha (TNFα) gene in adipose tissue was measured in two groups of Zucker Diabetic Sprague Dawley (ZDSD) rats after Roux-en-Y gastric bypass (RYGB) surgery or 'SHAM' operation. There was lower PCSK9 (p = 0.02) and higher LDLR gene expression (p = 0.02) in adipose tissue in rats after RYGB. Weight change did not correlate with PCSK9 gene expression (r = -0.5, p = 0.08) or TNFα gene expression (r = -0.4, p = 0.1). TNFα gene expression was positively correlated with PCSK9 gene expression (r = 0.7, p = 0.001) but not correlated with LDLR expression (r = -0.3, p = 0.3). Circulating triglyceride levels were lower in RYGB compared to the SHAM group (1.1 (0.8-1.4) vs. 1.5 (1.0-4.2), p = 0.038) mmol/L with no difference in cholesterol levels. LDLR gene expression was increased post-bariatric surgery with the potential to reduce the number of circulating LDL particles. PCSK9 gene expression and TNFα gene expression were positively correlated after RYGB in ZDSD rats, suggesting that the modulation of pro-inflammatory pathways in adipose tissue after RYGB may partly relate to PCSK9 and LDLR gene expression.Citation
Heald AH, Fachim HA, Bashir B, Garside B, Adam S, Iqbal Z, et al. Impact of Bariatric Surgery on ABC Subtilisin/Kexin Type 9 (PCSK9) Gene Expression and Inflammation in the Adipose Tissue of Obese Diabetic Rats. International journal of molecular sciences. 2023 Nov 30;24(23). PubMed PMID: 38069302. Pubmed Central PMCID: PMC10707086. Epub 2023/12/09. eng.Journal
International Journal of Molecular SciencesDOI
10.3390/ijms242316978PubMed ID
38069302Additional Links
https://dx.doi.org/10.3390/ijms242316978Type
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.3390/ijms242316978