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    Current evidence for immune checkpoint inhibition in advanced hepatocellular carcinoma

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    Authors
    Foy, Victoria
    McNamara, Mairead G
    Valle, Juan W
    Lamarca, Angela
    Edeline, J.
    Hubner, Richard A
    Affiliation
    Department of Medical Oncology, The Christie NHS Foundation Trust, Wilmslow Rd., Manchester M20 4BX, UK
    Issue Date
    2023
    
    Metadata
    Show full item record
    Abstract
    The treatment of advanced unresectable HCC (aHCC) remains a clinical challenge, with limited therapeutic options and poor prognosis. The results of IMbrave150 and HIMALAYA have changed the treatment paradigm for HCC and established immune checkpoint inhibition (ICI), either combined with anti-angiogenic therapy or dual ICI, as preferred first-line therapy for eligible patients with aHCC. Numerous other combination regimens involving ICI are under investigation with the aim of improving the tumour response and survival of patients with all stages of HCC. This review will explore the current evidence for ICI in patients with advanced HCC and discuss future directions, including the unmet clinical need for predictive biomarkers to facilitate patient selection, the effects of cirrhosis aetiology on response to ICI, and the safety of its use in patients with impaired liver function.
    Citation
    Foy V, McNamara MG, Valle JW, Lamarca A, Edeline J, Hubner RA. Current Evidence for Immune Checkpoint Inhibition in Advanced Hepatocellular Carcinoma. Current oncology (Toronto, Ont). 2023 Sep 21;30(9):8665-85. PubMed PMID: 37754543. Pubmed Central PMCID: PMC10529518. Epub 2023/09/27. eng.
    Journal
    Current Oncology
    URI
    http://hdl.handle.net/10541/626600
    DOI
    10.3390/curroncol30090628
    PubMed ID
    37754543
    Additional Links
    https://dx.doi.org/10.3390/curroncol30090628
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.3390/curroncol30090628
    Scopus Count
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