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    The journey from melanocytes to melanoma

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    Authors
    Centeno, Patricia P
    Pavet, Valeria
    Marais, Richard
    Affiliation
    Molecular Oncology Group, Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park, UK
    Issue Date
    2023
    
    Metadata
    Show full item record
    Abstract
    Over the past decade, melanoma has led the field in new cancer treatments, with impressive gains in on-treatment survival but more modest improvements in overall survival. Melanoma presents heterogeneity and transcriptional plasticity that recapitulates distinct melanocyte developmental states and phenotypes, allowing it to adapt to and eventually escape even the most advanced treatments. Despite remarkable advances in our understanding of melanoma biology and genetics, the melanoma cell of origin is still fiercely debated because both melanocyte stem cells and mature melanocytes can be transformed. Animal models and high-throughput single-cell sequencing approaches have opened new opportunities to address this question. Here, we discuss the melanocytic journey from the neural crest, where they emerge as melanoblasts, to the fully mature pigmented melanocytes resident in several tissues. We describe a new understanding of melanocyte biology and the different melanocyte subpopulations and microenvironments they inhabit, and how this provides unique insights into melanoma initiation and progression. We highlight recent findings on melanoma heterogeneity and transcriptional plasticity and their implications for exciting new research areas and treatment opportunities. The lessons from melanocyte biology reveal how cells that are present to protect us from the damaging effects of ultraviolet radiation reach back to their origins to become a potentially deadly cancer.
    Citation
    Centeno PP, Pavet V, Marais R. The journey from melanocytes to melanoma. Nat Rev Cancer. 2023 Apr 24. PubMed PMID: 37095242. Epub 2023/04/25. eng.
    Journal
    Nature Reviews Cancer
    URI
    http://hdl.handle.net/10541/626250
    DOI
    10.1038/s41568-023-00565-7
    PubMed ID
    37095242
    Additional Links
    https://dx.doi.org/10.1038/s41568-023-00565-7
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41568-023-00565-7
    Scopus Count
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    All Paterson Institute for Cancer Research

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