Randomised controlled trial of breast cancer and multiple disease prevention weight loss programmes vs written advice amongst women attending a breast cancer family history clinic
Name:
36841908.pdf
Size:
669.2Kb
Format:
PDF
Description:
Identified with Open Access button
Authors
Harvie, Michelle NFrench, David P
Pegington, Mary
Lombardelli, C.
Krizak, S.
Sellers, K.
Barrett, E.
Evans, D Gareth R
Cutress, R.
Wilding Rgn, A.
Graves, L.
Howell, Anthony
Affiliation
The Prevent Breast Cancer Research Unit, The Nightingale Centre, Manchester University NHS Foundation Trust, Manchester, M23 9LT, EnglandIssue Date
2023
Metadata
Show full item recordAbstract
Background: Overweight and obesity are common amongst women attending breast cancer Family History, Risk and Prevention Clinics (FHRPCs). Overweight increases risk of breast cancer (BC) and conditions including1 cardiovascular disease (CVD) and type-2 diabetes (T2D). Clinics provide written health behaviour advice with is likely to have minimal effects. We assessed efficacy of two remotely delivered weight loss programmes vs. written advice. Method: 210 women with overweight or obesity attending three UK FHRPCs were randomised to either a BC prevention programme (BCPP) framed to reduce risk of BC (n = 86), a multiple disease prevention programme (MDPP) framed to reduce risk of BC, CVD and T2D (n = 87), or written advice (n = 37). Change in weight and health behaviours were assessed at 12-months. Results: Weight loss at 12 months was -6.3% (-8.2, -4.5) in BCPP, -6.0% (-7.9, -4.2) in MDPP and -3.3% (-6.2, -0.5) in the written group (p = 0.451 across groups). The percentage losing ≥10% weight in these groups were respectively 34%, 23% and 14% (p = 0.038 across groups). Discussion: BCPP and MDPP programmes resulted in more women achieving ≥10% weight loss, but no evidence of additional benefits of MDPP. A multicentre RCT to test the BCPP across UK FHRPCs is warranted.Citation
Harvie M, French DP, Pegington M, Lombardelli C, Krizak S, Sellers K, et al. Randomised controlled trial of breast cancer and multiple disease prevention weight loss programmes vs written advice amongst women attending a breast cancer family history clinic. British journal of cancer. 2023 Feb 25:1-11. PubMed PMID: 36841908. Pubmed Central PMCID: PMC9961304 of an investigator-led Collaborative Research Agreement between SECA GmbH & Co. KG. (Hamburg, Germany), UHS and the University of Southampton. Also institutional research funding by Astra Zeneca (unrelated to this study). The other authors declare no competing interests. Epub 2023/02/26. eng.Journal
British Journal of CancerDOI
10.1038/s41416-023-02207-zPubMed ID
36841908Additional Links
https://dx.doi.org/10.1038/s41416-023-02207-zType
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.1038/s41416-023-02207-z
Scopus Count
Collections
Related articles
- Testing a breast cancer prevention and a multiple disease prevention weight loss programme amongst women within the UK NHS breast screening programme-a randomised feasibility study.
- Authors: Harvie M, French DP, Pegington M, Cooper G, Howell A, McDiarmid S, Lombardelli C, Donnelly L, Ruane H, Sellers K, Barrett E, Armitage CJ, Evans DG
- Issue date: 2021 Dec 20
- Breast cancer risk status influences uptake, retention and efficacy of a weight loss programme amongst breast cancer screening attendees: two randomised controlled feasibility trials.
- Authors: Harvie M, Pegington M, French D, Cooper G, McDiarmid S, Howell A, Donnelly L, Ruane H, Sellers K, Foden P, Evans DG
- Issue date: 2019 Dec 4
- The effectiveness of home versus community-based weight control programmes initiated soon after breast cancer diagnosis: a randomised controlled trial.
- Authors: Harvie M, Pegington M, McMullan D, Bundred N, Livingstone K, Campbell A, Wolstenholme J, Lovato E, Campbell H, Adams J, Speed S, Morris J, Howell S, Howell A
- Issue date: 2019 Sep
- Systematic reviews of and integrated report on the quantitative, qualitative and economic evidence base for the management of obesity in men.
- Authors: Robertson C, Archibald D, Avenell A, Douglas F, Hoddinott P, van Teijlingen E, Boyers D, Stewart F, Boachie C, Fioratou E, Wilkins D, Street T, Carroll P, Fowler C
- Issue date: 2014 May
- Tackling obesity in areas of high social deprivation: clinical effectiveness and cost-effectiveness of a task-based weight management group programme - a randomised controlled trial and economic evaluation.
- Authors: McRobbie H, Hajek P, Peerbux S, Kahan BC, Eldridge S, Trépel D, Parrott S, Griffiths C, Snuggs S, Myers Smith K
- Issue date: 2016 Oct