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    Treatment patterns and outcomes among patients with small-cell lung cancer (SCLC) in Europe: a retrospective cohort study

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    Authors
    Blackhall, Fiona H
    Girard, N.
    Livartowski, A.
    McDonald, L.
    Roset, M.
    Lara, N.
    Juarez García, A.
    Affiliation
    Lung Disease Cancer, The Christie NHS Foundation Trust, Manchester, UK
    Issue Date
    2023
    
    Metadata
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    Abstract
    Objective: Describe characteristics, treatment patterns and clinical outcomes of patients with small-cell lung cancer (SCLC). Design: Retrospective chart review study defining several cohorts: (1) limited-stage disease (LD) SCLC initiating 1L therapy (1 L LD-SCLC), (2) extensive-stage disease (ED) SCLC initiating 1L therapy (1L ED-SCLC) and (3) patients initiating 2L therapy. Setting: 39 physicians (medical oncologists, thoracic oncologists and/or pulmonologists) from France, Italy and the UK. Participants: Patients >18 years of age with a confirmed diagnosis of LD-SCLC or ED-SCLC and a full oncology medical history. Patients included initiated a 1L (2013-2015) or 2L (2013-2016) treatment (chemotherapy and/or radiotherapy-RT). Primary and secondary outcome measures: Overall survival (OS) and progression-free survival (PFS). Results: 231 patients in 1L LD-SCLC, 308 in 1L ED-SCLC and 225 with relapse/refractory SCLC initiating 2L treatment were included. The proportion of men was higher across all groups (56.8% to 68.5%) and mean age at time of diagnosis was 66.0 and 65.4 years in 1L LD-SCLC and 2L ED-SCLC cohorts. The majority of patients in LD-SCLC 1L group received chemotherapy with RT (76.2%). Patients initiating 2L therapy predominantly received chemotherapy alone (79.6%).Median OS in 1 L patients was 17.3 months in LD-SCLC and 8.8 months in ED-SCLC. Median PFS was 11.6 months in LD-SCLC and 6.1 months in ED-SCLC patients. Median OS in patients initiating 2L treatment was 6.6 months. OS from start of 2L treatment was lower in patients initially diagnosed with ED (5.1 months) than in patients initially diagnosed with LD (9.3 months) (p<0.0001). OS and PFS were assessed from the start of 1L or 2L therapy, depending on the cohort. Conclusions: Despite the availability of a high number of treatments and combinations, the prognosis of SCLC is still unsatisfactory, especially for those patients diagnosed with ED-SCLC, indicating high unmet need in this patient population.
    Citation
    Blackhall F, Girard N, Livartowski A, McDonald L, Roset M, Lara N, et al. Treatment patterns and outcomes among patients with small-cell lung cancer (SCLC) in Europe: a retrospective cohort study. BMJ open. 2023 Feb 6;13(2):e052556. PubMed PMID: 36746549. Epub 2023/02/07. eng.
    Journal
    BMJ Open
    URI
    http://hdl.handle.net/10541/626046
    DOI
    10.1136/bmjopen-2021-052556
    PubMed ID
    36746549
    Additional Links
    https://dx.doi.org/10.1136/bmjopen-2021-052556
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1136/bmjopen-2021-052556
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