Composite nanoarchitectonics of photoactivated titania-based materials with anticancer properties
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Authors
Papadopoulou-Fermeli, N.Lagopati, N.
Pippa, N.
Sakellis, E.
Boukos, N.
Gorgoulis, Vassilis G
Gazouli, M.
Pavlatou, E. A.
Affiliation
Laboratory of General Chemistry, School of Chemical Engineering, National Technical University of Athens, Zografou Campus, 15789 Zografou, GreeceIssue Date
2022
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The synthesis of titania-based composite materials with anticancer potential under visible-light irradiation is the aim of this study. In specific, titanium dioxide (TiO2) nanoparticles (NPs) chemically modified with silver were embedded in a stimuli-responsive microgel (a crosslinked interpenetrating network (IP) network that was synthesized by poly (N-Isopropylacrylamide) and linear chains of polyacrylic acid sodium salt, forming composite particles. The ultimate goal of this research, and for our future plans, is to develop a drug-delivery system that uses optical fibers that could efficiently photoactivate NPs, targeting cancer cells. The produced Ag-TiO2 NPs, the microgel and the composite materials were characterized through X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), micro-Raman spectroscopy, ultraviolet-visible spectroscopy (UV-Vis), dynamic light scattering (DLS) and transmission electron microscopy (TEM). Our results indicated that Ag-TiO2 NPs were successfully embedded within the thermoresponsive microgel. Either Ag-TiO2 NPs or the composite materials exhibited high photocatalytic degradation efficiency on the pollutant rhodamine B and significant anticancer potential under visible-light irradiation.Citation
Papadopoulou-Fermeli N, Lagopati N, Pippa N, Sakellis E, Boukos N, Gorgoulis VG, et al. Composite Nanoarchitectonics of Photoactivated Titania-Based Materials with Anticancer Properties. Pharmaceutics. 2022 Dec 30;15(1). PubMed PMID: 36678763. Pubmed Central PMCID: PMC9864881. Epub 2023/01/22. eng.Journal
PharmaceuticsDOI
10.3390/pharmaceutics15010135PubMed ID
36678763Additional Links
https://dx.doi.org/10.3390/pharmaceutics15010135Type
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enae974a485f413a2113503eed53cd6c53
10.3390/pharmaceutics15010135
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